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Activity studies of sesquiterpene oxides and sulfides from the plant Hyptis suaveolens (Lamiaceae) and its repellency on Ixodes ricinus (Acari:Ixodidae)
Yamagata Univ, Dept Bioenvirom, Fac Agr, Tsuruoka, Yamagata 9978555, Japan.;Royal Inst Technol, Sch Chem Sci & Engn, Ecol Chem Grp, Dept Chem, SE-10044 Stockholm, Sweden..
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Animal ecology.
Royal Inst Technol, Sch Chem Sci & Engn, Ecol Chem Grp, Dept Chem, SE-10044 Stockholm, Sweden..
Royal Inst Technol, Sch Chem Sci & Engn, Ecol Chem Grp, Dept Chem, SE-10044 Stockholm, Sweden.;Natl Univ Laos NOUL, Viangchan, Laos..
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2015 (English)In: Experimental & applied acarology, ISSN 0168-8162, E-ISSN 1572-9702, Vol. 67, no 4, 595-606 p.Article in journal (Refereed) Published
Abstract [en]

Hyptis suaveolens (Lamiaceae), a plant traditionally used as a mosquito repellent, has been investigated for repellent properties against nymphs of the tick Ixodes ricinus. Essential oils and volatile compounds of fresh and dried leaves, from plants originating from Laos and Guinea-Bissau, were identified by GC-MS and tested in a tick repellency bioassay. All the essential oils were strongly repellent against the ticks, even though the main volatile constituents differed in their proportions of potentially tick repellent chemicals. (+)/(-)-sabinene were present in high amounts in all preparations, and dominated the emission from dry and fresh leaves together with 1,8-cineol and alpha-phellandrene. 1,8-Cineol and sabinene were major compounds in the essential oils from H. suaveolens from Laos. Main compounds in H. suaveolens from Guinea-Bissau were (-)-sabinene, limonene and terpinolene. Among the sesquiterpene hydrocarbons identified, alpha-humulene exhibited strong tick repellency (96.8 %). Structure activity studies of oxidation or sulfidation products of germacrene D, alpha-humulene and beta-caryophyllene, showed increased tick repellent activity: of mint sulfide (59.4 %), humulene-6,7-oxide (94.5 %) and caryophyllene-6,7-oxide (96.9 %). The substitution of oxygen with sulfur slightly lowered the repellency. The effects of the constituents in the oils can then be regarded as a trade off between the subsequently lower volatility of the sesquiterpene derivatives compared to the monoterpenes and may thus increase their potential usefulness as tick repellents.

Place, publisher, year, edition, pages
2015. Vol. 67, no 4, 595-606 p.
Keyword [en]
Caryophyllene oxide, Caryophyllene sulfide, Essential oil, Hyptis suaveolens, Ixodes ricinus, Repellency
National Category
Zoology Ecology
URN: urn:nbn:se:uu:diva-268391DOI: 10.1007/s10493-015-9965-5ISI: 000364223100009PubMedID: 26385208OAI: oai:DiVA.org:uu-268391DiVA: diva2:878631
Sida - Swedish International Development Cooperation AgencySwedish Research Council FormasSwedish Research Council Formas
Available from: 2015-12-09 Created: 2015-12-04 Last updated: 2015-12-09Bibliographically approved

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