Effect of radiotherapy on expression of hyaluronan and EGFR and presence of mast cells in squamous cell carcinoma of the head and neck.
2012 (English)In: Oncology Letters, ISSN 1792-1074, E-ISSN 1792-1082, Vol. 4, no 6Article in journal (Refereed) Published
Head and neck squamous cell carcinoma is a common form of cancer, and despite improvements in treatment during the last decades, survival rates have not significantly increased. There is therefore a need to better understand how these tumours and the adjacent tissues react to radiotherapy, the most common type of treatment for this group of tumours. In order to improve this understanding, the expression of hyaluronan (HA) and epidermal growth factor receptor (EGFR) and the presence of mast cells were mapped before and after radiotherapy using immunohistochemistry. The results showed HA and EGFR to have similar expression patterns in tumour tissue and histologically normal squamous epithelium prior to radiotherapy. Following radiotherapy, EGFR increased in histologically normal epithelium. An increased number of mast cells were also observed as a result of radiotherapy. No expression of EGFR was observed in the connective tissue either prior to or following radiotherapy.
Place, publisher, year, edition, pages
2012. Vol. 4, no 6
Age; Body mass index; Cytokine; Human; Proximity extension assay (PEA); Cerebrospinal fluid
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-269490DOI: 10.3892/ol.2012.907PubMedID: 23205115OAI: oai:DiVA.org:uu-269490DiVA: diva2:883182