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Claes Hellerström and Cartesian Diver respirometry
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.ORCID iD: 0000-0002-5467-9755
2016 (English)In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 121, no 2, 77-80 p.Article in journal (Refereed) Published
Abstract [en]

Cartesian diver microrespirometry was introduced by Claes Hellerström at the Department of Histology/Medical Cell Biology at Uppsala University, Sweden, to determine rates of oxygen consumption in islets of Langerhans. The theory behind this method is touched upon and the main findings described. Glucose-stimulated beta cell respiration significantly contributes to increased ATP generation, which is a prerequisite for stimulated insulin secretion and synthesis. This has had major implications for understanding the beta cell stimulus secretion coupling.

Place, publisher, year, edition, pages
2016. Vol. 121, no 2, 77-80 p.
Keyword [sv]
Cartesian diver; glucose; insulin secretion; islets of Langerhans; respiration
National Category
Cell and Molecular Biology
URN: urn:nbn:se:uu:diva-269505DOI: 10.3109/03009734.2015.1109012ISI: 000376695600003PubMedID: 27181825OAI: oai:DiVA.org:uu-269505DiVA: diva2:883223
Swedish Diabetes Association
Available from: 2015-12-16 Created: 2015-12-16 Last updated: 2016-07-12Bibliographically approved

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