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Growth Hormone Treatment Improves Cognitive Function in Short Children with Growth Hormone Deficiency
Univ Gothenburg, Gothenborg Pediat Growth Res Ctr, Dept Pediat, Inst Clin Sci,Sahlgrenska Acad, SE-41685 Gothenburg, Sweden..
Umea Univ, Inst Clin Sci Pediat, Umea, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Pediatrics.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Pediatrics.
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2015 (English)In: Hormone Research in Paediatrics, ISSN 1663-2818, E-ISSN 1663-2826, Vol. 83, no 6, 390-399 p.Article in journal (Refereed) Published
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Abstract [en]

Background/Aims: We investigated the association between cognition and growth hormone (GH) status and GH treatment in short prepubertal children with broadly ranging GH secretion. Methods: A total of 99 children (age 3-11 years), 41 with GH deficiency (GHD) and 58 with idiopathic short stature (ISS), were randomized to a fixed dose (43 mu g/kg/day) or a prediction model-guided individualized dose (17-100 mu g/kg/day) and followed up for 24 months. In a longitudinal and mixed within-and between-subjects study, we examined clinical effect size changes, measured by Cohen's d, in full-scale IQ (FSIQ) and secondary IQ indices. Results: Significant increases giving medium effect size in FSIQ (p = 0.001, Cohen's d = 0.63), performance IQ (p = 0.001, Cohen's d = 0.65) and processing speed (p = 0.005, Cohen's d = 0.71) were found in the GH-deficient group. In contrast, perceptual organization only increased in the ISS group (p = 0.001, Cohen's d = 0.53). Baseline IQ was normally distributed with small but significant differences between the groups: GH-deficient children had lower FSIQ (p = 0.042) and lower performance IQ (p = 0.021). Using multiple regression analysis, 40% of the variance in delta processing speed scores (0-24 months) was explained by GH(max) and IGF-I-SDS at baseline. Conclusion: IQ, specifically fluid intelligence, increased in the GH-deficient children. The pretreatment status of the GH/IGF-I axis was significantly predictive for these changes. 

Place, publisher, year, edition, pages
2015. Vol. 83, no 6, 390-399 p.
Keyword [en]
Cognition, IQ, Insulin-like growth factor I, Short stature, Fluid intelligence, Idiopathic short stature
National Category
Pediatrics Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:uu:diva-269786DOI: 10.1159/000375529ISI: 000357834800003OAI: oai:DiVA.org:uu-269786DiVA: diva2:885346
Funder
Swedish Research Council, 7509
Available from: 2015-12-18 Created: 2015-12-18 Last updated: 2017-12-01Bibliographically approved

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Tuvemo, Torsten

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