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An introduction to MS imaging in drug discovery and development
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
2015 (English)In: Bioanalysis, ISSN 1757-6180, E-ISSN 1757-6199, Vol. 7, no 20, 2621-2627 p.Article in journal (Refereed) Published
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Abstract [en]

A vital process in drug discovery and development is to assess the absorption, distribution, metabolism, excretion and toxicology of potentially therapeutic compounds in the body. The potential utility of MS imaging has been demonstrated in many studies focusing on molecules including peptides, proteins and lipids. However, MS imaging also permits the direct analysis of drugs and drug metabolites in tissue samples without requiring the use of target-specific labels or reagents. Here, a brief technical description of the technique is presented along with examples of its usefulness at different stages of the drug discovery and development process including absorption, distribution, metabolism, excretion and toxicology, and blood-brain barrier drug penetration investigations.

Place, publisher, year, edition, pages
2015. Vol. 7, no 20, 2621-2627 p.
National Category
Pharmaceutical Sciences Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:uu:diva-269999DOI: 10.4155/bio.15.186ISI: 000364786600003PubMedID: 26511071OAI: oai:DiVA.org:uu-269999DiVA: diva2:885577
Funder
Swedish Research Council, 2008-5597Swedish Research Council, 2013-3105Swedish Research Council, 2014-6215Swedish Research Council, 2009-6050
Available from: 2015-12-19 Created: 2015-12-19 Last updated: 2017-12-01Bibliographically approved

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Shariatgorji, MohammadrezaNilsson, AnnaAndrén, Per E.

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