An introduction to MS imaging in drug discovery and development
2015 (English)In: Bioanalysis, ISSN 1757-6180, E-ISSN 1757-6199, Vol. 7, no 20, 2621-2627 p.Article in journal (Refereed) PublishedText
A vital process in drug discovery and development is to assess the absorption, distribution, metabolism, excretion and toxicology of potentially therapeutic compounds in the body. The potential utility of MS imaging has been demonstrated in many studies focusing on molecules including peptides, proteins and lipids. However, MS imaging also permits the direct analysis of drugs and drug metabolites in tissue samples without requiring the use of target-specific labels or reagents. Here, a brief technical description of the technique is presented along with examples of its usefulness at different stages of the drug discovery and development process including absorption, distribution, metabolism, excretion and toxicology, and blood-brain barrier drug penetration investigations.
Place, publisher, year, edition, pages
2015. Vol. 7, no 20, 2621-2627 p.
Pharmaceutical Sciences Radiology, Nuclear Medicine and Medical Imaging
IdentifiersURN: urn:nbn:se:uu:diva-269999DOI: 10.4155/bio.15.186ISI: 000364786600003PubMedID: 26511071OAI: oai:DiVA.org:uu-269999DiVA: diva2:885577
FunderSwedish Research Council, 2008-5597Swedish Research Council, 2013-3105Swedish Research Council, 2014-6215Swedish Research Council, 2009-6050