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Mitogenomic analysis of a 50-generation chicken pedigree reveals a rapid rate of mitochondrial evolution and evidence for paternal mtDNA inheritance
Univ York, York YO10 5DD, N Yorkshire, England.;Univ Aberdeen, Sch Geosci, Dept Archaeol, Aberdeen AB24 3UF, Scotland..
Univ Sydney, Sch Biol Sci, Sydney, NSW 2006, Australia..
Polish Acad Sci, Museum & Inst Zool, PL-00679 Warsaw, Poland..
Palaeogen & Bioarchaeol Res Network, Res Lab Archaeol, Oxford OX1 3QY, England..
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2015 (English)In: Biology Letters, ISSN 1744-9561, E-ISSN 1744-957X, Vol. 11, no 10, 20150561Article in journal (Refereed) Published
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Abstract [en]

Mitochondrial genomes represent a valuable source of data for evolutionary research, but studies of their short-term evolution have typically been limited to invertebrates, humans and laboratory organisms. Here we present a detailed study of 12 mitochondrial genomes that span a total of 385 transmissions in a well-documented 50-generation pedigree in which two lineages of chickens were selected for low and high juvenile body weight. These data allowed us to test the hypothesis of time-dependent evolutionary rates and the assumption of strict maternal mitochondrial transmission, and to investigate the role of mitochondrial mutations in determining phenotype. The identification of a non-synonymous mutation in ND4L and a synonymous mutation in CYTB, both novel mutations in Gallus, allowed us to estimate a molecular rate of 3.13 x 10(-7) mutations/site/year (95% confidence interval 3.75 x 10(-8)-1.12 x 10(-6)). This is substantially higher than avian rate estimates based upon fossil calibrations. Ascertaining which of the two novel mutations was present in an additional 49 individuals also revealed an instance of paternal inheritance of mtDNA. Lastly, an association analysis demonstrated that neither of the point mutations was strongly associated with the phenotypic differences between the two selection lines. Together, these observations reveal the highly dynamic nature of mitochondrial evolution over short time periods.

Place, publisher, year, edition, pages
2015. Vol. 11, no 10, 20150561
Keyword [en]
mitochondrial genome, pedigree, mutation rates, paternal leakage, association analysis
National Category
Other Basic Medicine Evolutionary Biology Ecology
Identifiers
URN: urn:nbn:se:uu:diva-269992DOI: 10.1098/rsbl.2015.0561ISI: 000364774700003OAI: oai:DiVA.org:uu-269992DiVA: diva2:885584
Funder
EU, European Research Council, ERC-2013-StG 337574-UNDEAD
Available from: 2015-12-19 Created: 2015-12-19 Last updated: 2017-12-01Bibliographically approved

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Carlborg, ÖrjanWahlberg, PerAndersson, Leif

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