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Tritium labeling of a class of spirooxazaindolamines possessing analgesic properties.
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2004 (English)In: Synth. Appl. Isot. Labelled Compd., Proc. Int. Symp., 8th, 2004, 285-288 p.Conference paper, Poster (with or without abstract) (Refereed)
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Text
Abstract [en]

In order to study the mol. action of a class of spirooxazaindolamines with promising analgesic activity, tritiated material was prepd. Efficient synthesis of 3H-labeled material allowed essential information on the mol. mechanism for this class of compds. to be obtained. Different approaches for the introduction of the 3H-label on the spirooxazaindole skeleton via 3H-methyliodide were evaluated involving lithium-mediated coupling, zinc-mediated coupling and Stille coupling. Tritiation using 3H2 (g) with a Pd-catalyst was also tested. [on SciFinder(R)]

Place, publisher, year, edition, pages
2004. 285-288 p.
Keyword [en]
spirooxazaindolamine tritiation methyliodide
National Category
Medicinal Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-270239OAI: oai:DiVA.org:uu-270239DiVA: diva2:888184
Conference
Synth. Appl. Isot. Labelled Compd., Proc. Int. Symp., 8th
Note

Synthesis and Applications of Isotopically Labelled Compounds, Proceedings of the International Symposium, 8th, Boston, MA, United States, June 1-5, 2003

Available from: 2015-12-22 Created: 2015-12-22 Last updated: 2015-12-22

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Yngve, Ulrika

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