Tritium labeling of a class of spirooxazaindolamines possessing analgesic properties.
2004 (English)In: Synth. Appl. Isot. Labelled Compd., Proc. Int. Symp., 8th, 2004, 285-288 p.Conference paper, Poster (Refereed)Text
In order to study the mol. action of a class of spirooxazaindolamines with promising analgesic activity, tritiated material was prepd. Efficient synthesis of 3H-labeled material allowed essential information on the mol. mechanism for this class of compds. to be obtained. Different approaches for the introduction of the 3H-label on the spirooxazaindole skeleton via 3H-methyliodide were evaluated involving lithium-mediated coupling, zinc-mediated coupling and Stille coupling. Tritiation using 3H2 (g) with a Pd-catalyst was also tested. [on SciFinder(R)]
Place, publisher, year, edition, pages
2004. 285-288 p.
spirooxazaindolamine tritiation methyliodide
IdentifiersURN: urn:nbn:se:uu:diva-270239OAI: oai:DiVA.org:uu-270239DiVA: diva2:888184
Synth. Appl. Isot. Labelled Compd., Proc. Int. Symp., 8th
Synthesis and Applications of Isotopically Labelled Compounds, Proceedings of the International Symposium, 8th, Boston, MA, United States, June 1-5, 20032015-12-222015-12-222015-12-22