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Betatrophin in Diabetes Mellitus: the Epidemiological Evidence in Humans
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
2015 (English)In: Current Diabetes Reports, ISSN 1534-4827, E-ISSN 1539-0829, Vol. 15, no 12, 104Article, review/survey (Refereed) Published
Abstract [en]

The prevalence of type 2 diabetes is increasing worldwide, and while numerous treatments exist, none of the current pharmacologic therapies is curative. Pharmacologic approaches that increase beta cell mass may present an avenue for actual cure. There have been numerous reports on factors that can induce beta cell proliferation in rodents, whereas there are still very limited data on the occurrence of beta cell proliferation in humans. The recent discovery of the hormone betatrophin, which in mice counteracted glucose intolerance induced by insulin resistance by potently stimulating beta cell proliferation, has boosted the hope for a new target for drug development for the treatment of diabetes mellitus in humans. With the encouraging preclinical findings as a background, this review presents the available clinical data on betatrophin and discusses its possible role in humans.

Place, publisher, year, edition, pages
2015. Vol. 15, no 12, 104
Keyword [en]
Betatrophin; Diabetes; Humans; Beta cell proliferation; Islet; Liver
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:uu:diva-270683DOI: 10.1007/s11892-015-0676-4ISI: 000366806700002PubMedID: 26458375OAI: oai:DiVA.org:uu-270683DiVA: diva2:890345
Funder
Swedish Research Council, K2013-55X-15043Novo NordiskAFA InsuranceSwedish Diabetes AssociationSwedish Child Diabetes FoundationStiftelsen Olle Engkvist ByggmästareNovo Nordisk
Available from: 2016-01-03 Created: 2016-01-03 Last updated: 2017-12-01Bibliographically approved

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Espes, DanielMartinell, MatsLiljebäck, HannaCarlsson, Per-Ola

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