uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Performance and complications of lumbar puncture in memory clinics: Results of the multicenter lumbar puncture feasibility study
Show others and affiliations
2016 (English)In: Alzheimer's & Dementia, ISSN 1552-5260, E-ISSN 1552-5279, Vol. 12, no 2, 154-163 p.Article in journal (Refereed) Published
Abstract [en]

INTRODUCTION: Lumbar puncture (LP) is increasingly performed in memory clinics. We investigated patient-acceptance of LP, incidence of and risk factors for post-LP complications in memory clinic populations.

METHODS: We prospectively enrolled 3868 patients (50% women, age 66 ± 11 years, mini mental state examination 25 ± 5) at 23 memory clinics. We used logistic regression analysis using generalized estimated equations to investigate risk factors for post-LP complications, such as typical postlumbar puncture headache (PLPH) and back pain.

RESULTS: A total of 1065 patients (31%) reported post-LP complaints; 589 patients (17%) reported back pain, 649 (19%) headache, of which 296 (9%) reported typical PLPH. Only few patients needed medical intervention: 11 (0.3%) received a blood patch, 23 (0.7%) were hospitalized. The most important risk factor for PLPH was medical history of headache. An atraumatic needle and age >65 years were preventive. Gender, rest after LP, or volume of cerebrospinal fluid had no effect.

DISCUSSIONS: The overall risk of complications is relatively low. If risk factors shown in this study are taken into account, LPs can be safely performed in memory clinics.

Place, publisher, year, edition, pages
2016. Vol. 12, no 2, 154-163 p.
Keyword [en]
Lumbar puncture; Cognitive disorders; Alzheimer's disease; Memory clinic; Post-LP complications; Post-LP headache; Multicenter study on LP feasibility
National Category
URN: urn:nbn:se:uu:diva-270773DOI: 10.1016/j.jalz.2015.08.003ISI: 000369523500007PubMedID: 26368321OAI: oai:DiVA.org:uu-270773DiVA: diva2:890522
Swedish Research Council, 14002
Available from: 2016-01-04 Created: 2016-01-04 Last updated: 2016-03-02Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Ingelsson, Martin
By organisation
In the same journal
Alzheimer's & Dementia

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 181 hits
ReferencesLink to record
Permanent link

Direct link