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Warfarin persistence among stroke patients with atrial fibrillation
Umea Univ, Dept Publ Hlth & Clin Med, S-90187 Umea, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
Lund Univ, Dept Coagulat Disorders, Malmö, Sweden..
Umea Univ, Dept Publ Hlth & Clin Med, S-90187 Umea, Sweden..
2015 (English)In: Thrombosis Research, ISSN 0049-3848, E-ISSN 1879-2472, Vol. 136, no 4, 744-748 p.Article in journal (Refereed) PublishedText
Abstract [en]

Introduction: Warfarin treatment discontinuation is significant among patients with atrial fibrillation (AF). For AF patients with stroke a warfarin persistence rate of 0.45 after 2 years has previously been reported. No consistent predictors for discontinuation have been established. Aims: Evaluation of warfarin persistence and variables associated with discontinuation, in a large Swedish cohort with unselected stroke/TIA patients with AF treated with warfarin. Materials and methods: 4 583 patients with stroke/TIA and AF in the Swedish National Patient Register (NPR), from 1. Jan 2006 to 31. Dec 2011, were matched with the Swedish national quality register AuriculA. They were followed until treatment cessation, death or end of study. Baseline characteristics and CHA(2)DS(2)VASc score were retrieved from NPR. Treatment-time was retrieved from AuriculA. Results: Overall proportion of warfarin persistence was 0.78 (95% confidence interval (CI) 0.76 to 0.80) after one year, 0.69 (95% CI 0.67 to 0.71) after 2 years and 0.47 (95% CI 0.43 to 0.51) after 5 years. Variables clearly associated with higher discontinuation were dementia (hazard ratio (HR) 2.22, CI 1.51-3.27) and alcohol abuse (HR 1.66, CI 1.19-2.33). Chronic obstructive pulmonary disease (COPD), cancer and chronic heart failure (CHF) were each associated with over 20% increased risk of treatment discontinuation. Higher CHA(2)DS(2)VASc score and start-age lead to lower persistence (p < 0.001). Conclusions: Persistence to warfarin in unselected stroke/TIA patients with AF is in Sweden greater than previously reported. Lower persistence is found among patients with high treatment start-age, incidence of dementia, alcohol abuse, cancer, CHF, COPD and/or high CHA(2)DS(2)VASc score.

Place, publisher, year, edition, pages
2015. Vol. 136, no 4, 744-748 p.
Keyword [en]
Atrial fibrillation, Discontinuation, Persistence, Stroke, Treatment, Warfarin
National Category
Cardiac and Cardiovascular Systems Hematology
URN: urn:nbn:se:uu:diva-271055DOI: 10.1016/j.thromres.2015.07.028ISI: 000365800600009PubMedID: 26254195OAI: oai:DiVA.org:uu-271055DiVA: diva2:891082
Available from: 2016-01-05 Created: 2016-01-05 Last updated: 2016-01-14Bibliographically approved

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Renlund, Henrik
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