Effect of genetic and environmental factors on protein biomarkers for common non-communicable disease and use of personally normalized plasma protein profiles (PNPPP)
2015 (English)In: Biomarkers, ISSN 1354-750X, E-ISSN 1366-5804, Vol. 20, no 6-7, 355-364 p.Article in journal (Refereed) PublishedText
Objective: To study the impact of genetic and lifestyle factors on protein biomarkers and develop personally normalized plasma protein profiles (PNPPP) controlling for non-disease-related variance.Materials and methods: Proximity extension assays were used to measure 145 proteins in 632 controls and 344 cases with non-communicable diseases.Results: Genetic and lifestyle factors explained 20-88% of the variation in healthy controls. Adjusting for these factors reduced the number of candidate biomarkers by 63%.Conclusion: PNPPP efficiently controls for non-disease-related variance, allowing both for efficient discovery of novel biomarkers and for covariate-independent linear cut-offs suitable for clinical use.
Place, publisher, year, edition, pages
2015. Vol. 20, no 6-7, 355-364 p.
Non-communicable diseases, normalization, plasma protein biomarkers, proximity extension assay
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
IdentifiersURN: urn:nbn:se:uu:diva-271044DOI: 10.3109/1354750X.2015.1093546ISI: 000365651700002PubMedID: 26551787OAI: oai:DiVA.org:uu-271044DiVA: diva2:891092
FunderSwedish National Infrastructure for Computing (SNIC), b2011203Swedish National Infrastructure for Computing (SNIC), p2013140