Effect of Consecutively Applied Fluorescein Eye Drops on Corneal and Aqueous Concentrations of Fluorescein
1997 (English)In: Ophthalmic Research, ISSN 0030-3747, E-ISSN 1423-0259, Vol. 29, 57 p.57-60 p.Article in journal (Refereed) Published
The main objective of this study was to determine the intraocular concentration of fluorescein after applying five eye drops with only 1-min intervals in human eyes. The concentration of fluorescein in cornea and aqueous was studied with fluorophotometry in 11 healthy volunteers. Five 10-μl drops of 2% fluorescein solution were administered with 1-min intervals, and the intraocular concentrations that were achieved were compared with those obtained with just one eye drop. Five consecutive fluorescein drops caused a 2.6- to 3.1-fold increase in fluorescein concentrations of the anterior chamber 1–8 h after application compared with a single eye drop (p < 0.05). Corresponding values for the cornea were 2.1–2.8. As a conclusion, administration of five eye drops applied consecutively significantly increases intraocular drug concentration during 8 h in humans.
Place, publisher, year, edition, pages
1997. Vol. 29, 57 p.57-60 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-61325DOI: 10.1159/000267997OAI: oai:DiVA.org:uu-61325DiVA: diva2:89236