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Fabrication of translucent nanoceramics via a simple filtration method
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
McMaster Univ, Dept Mat Sci & Engn, Hamilton, ON, Canada..
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
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2015 (English)In: RSC Advances, ISSN 2046-2069, E-ISSN 2046-2069, Vol. 5, no 121, 99848-99855 p.Article in journal (Refereed) PublishedText
Abstract [en]

Generally, particle packing density, grain size and morphology are the important factors that affect the transparency of ceramics. In order to achieve better transparency of ceramics, efforts should be developed to eliminate or minimize light scattering or absorption. Therefore the porosity and size of crystals in a ceramic body should be strictly controlled. Typical transparent ceramics are fabricated by pressure-assisted sintering techniques such as hot isostatic pressing (HIP), spark plasma sintering (SPS), and pressure-less sintering (PLS). However, a simple energy efficient production method remains a challenge. In this study, we describe a simple fabrication process via a facile filtration system that can fabricate translucent hydroxyapatite based ceramics. The translucent pieces yielded from filtration exhibit optical transmittance that was confirmed by UV spectroscopy. Briefly, the morphology and size of ceramic nanoparticles, filtration pressure and filtration time are important parameters to be discussed. Compared with different hydroxyapatite nanoparticles, spherical nanoparticles easily form a densely packed structure, followed by sintered ceramics. When the strontium content in HA increases, the morphology of HA changes from nano-spheres to nano-rods, following a decrease in transparency. A pressure filtration model combining Darcy's law and the Kozeny-Carman relation has been discussed to simulate and explain why the translucent ceramics can be fabricated via such a simple process. This method could be further applied to prepare other translucent functional ceramics by controlling the size and morphology of ceramic particles.

Place, publisher, year, edition, pages
2015. Vol. 5, no 121, 99848-99855 p.
National Category
Nano Technology Chemical Engineering
URN: urn:nbn:se:uu:diva-271611DOI: 10.1039/c5ra17866eISI: 000365406800033OAI: oai:DiVA.org:uu-271611DiVA: diva2:892873
Carl Tryggers foundation , 14:525
Available from: 2016-01-11 Created: 2016-01-11 Last updated: 2016-05-13Bibliographically approved
In thesis
1. Bio-Nano Interactions: Synthesis, Functionalization and Characterization of Biomaterial Interfaces
Open this publication in new window or tab >>Bio-Nano Interactions: Synthesis, Functionalization and Characterization of Biomaterial Interfaces
2016 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Current strategies for designing biomaterials involve creating materials and interfaces that interact with biomolecules, cells and tissues.  This thesis aims to investigate several bioactive surfaces, such as nanocrystalline diamond (NCD), hydroxyapatite (HA) and single crystalline titanium dioxide, in terms of material synthesis, surface functionalization and characterization.

Although cochlear implants (CIs) have been proven to be clinically successful, the efficiency of these implants still needs to be improved. A CI typically only has 12-20 electrodes while the ear has approximately 3400 inner hair cells. A type of micro-textured NCD surface that consists of micrometre-sized nail-head-shaped pillars was fabricated. Auditory neurons showed a strong affinity for the surface of the NCD pillars, and the technique could be used for neural guidance and to increase the number of stimulation points, leading to CIs with improved performance.

Typical transparent ceramics are fabricated using pressure-assisted sintering techniques. However, the development of a simple energy-efficient production method remains a challenge. A simple approach to fabricating translucent nano-ceramics was developed by controlling the morphology of the starting ceramic particles. Translucent nano-ceramics, including HA and strontium substituted HA, could be produced via a simple filtration process followed by pressure-less sintering. Furthermore, the application of such materials as a window material was investigated. The results show that MC3T3 cells could be observed through the translucent HA ceramic for up to 7 days. The living fluorescent staining confirmed that the MC3T3 cells were visible throughout the culture period.

Single crystalline rutile possesses in vitro bioactivity, and the crystalline direction affects HA formation. The HA growth on (001), (100) and (110) faces was investigated in a simulated body fluid in the presence of fibronectin (FN) via two different processes. The HA layers on each face were analysed using different characterization techniques, revealing that the interfacial energies could be altered by the pre-adsorbed FN, which influenced HA formation.

In summary, micro textured NCD, and translucent HA and FN functionalized single crystalline rutile, and their interactions with cells and biomimetic HA were studied. The results showed that controlled surface properties are important for enhancing a material’s biological performance.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2016. 37 p.
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1651-6214 ; 1345
Bioactive surfaces, nanocrystalline diamond, hydroxyapatite, protein secondary structure, protein absorption, auditory neurons, single crystalline rutile, nano morphology, surface functionalisation, in vitro biomineralisation, translucent nano-ceramics, bio-window material, material characterisation.
National Category
Engineering and Technology
Research subject
Engineering Science with specialization in Materials Science
urn:nbn:se:uu:diva-277121 (URN)978-91-554-9478-0 (ISBN)
Public defence
2016-06-01, Häggsalen, Ångströmlaboratoriet, Lägerhyddsvägen 1, Uppsala, 10:15 (English)
Available from: 2016-05-11 Created: 2016-02-17 Last updated: 2016-06-01

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