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Total-tau and neurofilament light in CSF reflect spinal cord ischaemia after endovascular aortic repair
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2016 (English)In: Neurochemistry International, ISSN 0197-0186, E-ISSN 1872-9754, Vol. 93, 1-5 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Repair of extensive aortic disease may be associated with spinal cord ischaemia (SCI). Here we test if levels of cerebrospinal fluid (CSF) biomarkers for neuronal injury are altered in patients with SCI after advanced endovascular repair of extensive aortic disease.

METHODS: CSF was sampled for up to 48 hours in ten patients undergoing endovascular aortic repair and analyzed for the axonal damage markers total-tau (T-tau) and neurofilament light (NFL).

RESULTS: Six of ten patients developed SCI (clinically present within 3-6 hours). CSF levels of NFL increased up to 37-fold in patients with, but were stable in patients without, SCI. CSF levels of T-tau also increased in patients with SCI, but with some overlap with patients without SCI. Levels of NFL and T-tau did not increase until after the appearance of neurological symptoms (12-48 h after aortic repair).

CONCLUSIONS: The CSF biomarkers NFL and T-tau both reflect development of SCI after endovascular aortic repair, but do not rise until after clinical signs of SCI appear. Future studies are desirable to identify earlier biomarkers of SCI.

Place, publisher, year, edition, pages
2016. Vol. 93, 1-5 p.
National Category
Neurology Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:uu:diva-272373DOI: 10.1016/j.neuint.2015.12.003ISI: 000371554700001PubMedID: 26682901OAI: oai:DiVA.org:uu-272373DiVA: diva2:893878
Funder
Swedish Research CouncilKnut and Alice Wallenberg Foundation
Available from: 2016-01-13 Created: 2016-01-13 Last updated: 2017-11-30Bibliographically approved

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Pikwer, Andreas

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Centrum för klinisk forskning i Sörmland (CKFD)
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