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Transgenerational effects of 17 alpha-ethinyl estradiol on anxiety behavior in the guppy, Poecilia reticulata
Sodertorn Univ, Sch Nat Sci Technol & Environm Studies, SE-14186 Huddinge, Sweden.;Univ Orebro, Sch Sci & Technol, Orebro Life Sci Ctr, SE-17082 Orebro, Sweden..
Sodertorn Univ, Sch Nat Sci Technol & Environm Studies, SE-14186 Huddinge, Sweden.;Univ Orebro, Sch Sci & Technol, Orebro Life Sci Ctr, SE-17082 Orebro, Sweden..
Sodertorn Univ, Sch Nat Sci Technol & Environm Studies, SE-14186 Huddinge, Sweden..
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Environmental toxicology. Sodertorn Univ, Sch Nat Sci Technol & Environm Studies, SE-14186 Huddinge, Sweden..
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2015 (English)In: General and Comparative Endocrinology, ISSN 0016-6480, E-ISSN 1095-6840, Vol. 223, 66-72 p.Article in journal (Refereed) Published
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Text
Abstract [en]

Environmental contaminants can cause alterations that can be transgenerationally transmitted to subsequent generations. Estrogens are among those contaminants shown to induce heritable changes that persist over generations in mammals. Results in other vertebrates are few. We have analyzed the effects on anxiety of 17 alpha-ethinyl estradiol (EE2) in the F1 and F2 generations in guppies, Poecilia reticulate, obtained from F0 fish maternally exposed to 0 or 20 ng/L EE2 until birth. F0 males and females were bred with fish of the same treatment but different families producing F1 offspring. Behavior in the novel tank test at 6 months revealed that males with EE2-exposed parents had significantly longer latency to the upper half of the tank than control males, while no EE2 effects were observed in females. Also in F2, obtained from F1 as above, males in the EE2 group had longer latency time compared to control males, with no differences due to EE2-exposure of F0 observed in females. In the scototaxis (light/dark preference) test, latency to first transition to black compartment and total transitions to black were significantly altered in females due to EE2 exposure of F0 while the total time in black was higher in males with EE2-exposed F0 compared with controls. The increased anxiety in the F2 generation demonstrates a transgenerational anxiety phenotype and shows that non-reproductive behavior can be transgenerationally modified by estrogens in fish.

Place, publisher, year, edition, pages
2015. Vol. 223, 66-72 p.
Keyword [en]
Transgenerational effects, 17 alpha-Ethinyl estradiol, EDCs, Fish, Behavior, Novel tank, Scototaxis
National Category
Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:uu:diva-272302DOI: 10.1016/j.ygcen.2015.09.027ISI: 000366438300008PubMedID: 26431611OAI: oai:DiVA.org:uu-272302DiVA: diva2:894244
Funder
Stockholm County CouncilThe Foundation for Baltic and East European Studies
Available from: 2016-01-14 Created: 2016-01-13 Last updated: 2017-11-30Bibliographically approved

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Hallgren, Stefan

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