uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Heritability of endometriosis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Reproduktionsbiologi)
Show others and affiliations
2015 (English)In: Fertility and Sterility, ISSN 0015-0282, E-ISSN 1556-5653, Vol. 104, no 4, 947-952 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To estimate the relative contribution of genetic influences and prevalence on endometriosis.

DESIGN: Analysis of self-reported data from a nationwide population-based twin registry.

SETTING: Not applicable.

PATIENT(S): A total of 28,370 women, female monozygotic (MZ) or dizygotic (DZ) twins, who participated in either of two surveys (1998-2002 or 2005-2006).


MAIN OUTCOME MEASURE(S): Self-reported endometriosis, validated by medical records.

RESULT(S): A history of endometriosis was reported by 1,228 female twins. The probandwise concordance was 0.21 for MZ and 0.10 for DZ twins. Higher within-pair (tetrachoric) correlation was observed among MZ (0.47) compared with DZ (0.20) twins. The best-fitting model revealed a contribution of 47% by additive genetic factors and the remaining 53% attributed to unique environmental effects.

CONCLUSION(S): Our findings suggest both genetic and unique (nonshared) environmental influences on the complex etiology of endometriosis and support the hypothesis that genes have a strong influence on phenotypic manifestations of endometriosis.

Place, publisher, year, edition, pages
2015. Vol. 104, no 4, 947-952 p.
Keyword [en]
Concordance; endometriosis; heritability; twins
National Category
Obstetrics, Gynecology and Reproductive Medicine
URN: urn:nbn:se:uu:diva-272548DOI: 10.1016/j.fertnstert.2015.06.035ISI: 000366485700025PubMedID: 26209831OAI: oai:DiVA.org:uu-272548DiVA: diva2:894388
The Karolinska Institutet's Research FoundationSwedish Research CouncilAstraZenecaNIH (National Institute of Health), DK066134NIH (National Institute of Health), CA085739
Available from: 2016-01-14 Created: 2016-01-14 Last updated: 2016-01-21Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Olovsson, Matts
By organisation
Department of Women's and Children's Health
In the same journal
Fertility and Sterility
Obstetrics, Gynecology and Reproductive Medicine

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 36 hits
ReferencesLink to record
Permanent link

Direct link