Heritability of endometriosis
2015 (English)In: Fertility and Sterility, ISSN 0015-0282, E-ISSN 1556-5653, Vol. 104, no 4, 947-952 p.Article in journal (Refereed) Published
OBJECTIVE: To estimate the relative contribution of genetic influences and prevalence on endometriosis.
DESIGN: Analysis of self-reported data from a nationwide population-based twin registry.
SETTING: Not applicable.
PATIENT(S): A total of 28,370 women, female monozygotic (MZ) or dizygotic (DZ) twins, who participated in either of two surveys (1998-2002 or 2005-2006).
MAIN OUTCOME MEASURE(S): Self-reported endometriosis, validated by medical records.
RESULT(S): A history of endometriosis was reported by 1,228 female twins. The probandwise concordance was 0.21 for MZ and 0.10 for DZ twins. Higher within-pair (tetrachoric) correlation was observed among MZ (0.47) compared with DZ (0.20) twins. The best-fitting model revealed a contribution of 47% by additive genetic factors and the remaining 53% attributed to unique environmental effects.
CONCLUSION(S): Our findings suggest both genetic and unique (nonshared) environmental influences on the complex etiology of endometriosis and support the hypothesis that genes have a strong influence on phenotypic manifestations of endometriosis.
Place, publisher, year, edition, pages
2015. Vol. 104, no 4, 947-952 p.
Concordance; endometriosis; heritability; twins
Obstetrics, Gynecology and Reproductive Medicine
IdentifiersURN: urn:nbn:se:uu:diva-272548DOI: 10.1016/j.fertnstert.2015.06.035ISI: 000366485700025PubMedID: 26209831OAI: oai:DiVA.org:uu-272548DiVA: diva2:894388
FunderThe Karolinska Institutet's Research FoundationSwedish Research CouncilAstraZenecaNIH (National Institute of Health), DK066134NIH (National Institute of Health), CA085739