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Immunizing with mouse trophoblast to obtain mouse-human cross-reacting antibodies against normal and neoplastic human trophoblast.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Reproduktionsbiologi)
1999 (English)In: Hybridoma, ISSN 0272-457X, E-ISSN 2168-7897, Vol. 18, no 6Article in journal (Refereed) Published
Abstract [en]

Monoclonal antibodies raised against living, early invasive mouse trophoblast cells were screened on paraffin sections from first- and third-trimester placentas and from hydatidiform moles and choriocarcinoma. Several mouse-human cross-reacting antibodies were recognized, which implies that mouse trophoblast cells can be used as immunogen for producing antibodies against human trophoblast. Among the new antibodies obtained, some were selected for further study. That panel includes a trophoblast specific antibody with capacity to differ between invasive and noninvasive molar tissues, and two antibodies, which detect antigen epitopes in the normal, but not in the neoplastic trophoblast.

Place, publisher, year, edition, pages
1999. Vol. 18, no 6
National Category
Obstetrics, Gynecology and Reproductive Medicine
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URN: urn:nbn:se:uu:diva-272615PubMedID: 10626682OAI: oai:DiVA.org:uu-272615DiVA: diva2:894403
Available from: 2016-01-14 Created: 2016-01-14 Last updated: 2017-11-30

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