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Targeting vascular and leukocyte communication in angiogenesis, inflammation and fibrosis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology, Integrative Physiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology, Integrative Physiology.
2016 (English)In: Nature reviews. Drug discovery, ISSN 1474-1776, E-ISSN 1474-1784, Vol. 15, no 2, 125-142 p.Article, review/survey (Refereed) Published
Abstract [en]

Regulation of vascular permeability, recruitment of leukocytes from blood to tissue and angiogenesis are all processes that occur at the level of the microvasculature during both physiological and pathological conditions. The interplay between microvascular cells and leukocytes during inflammation, together with the emerging roles of leukocytes in the modulation of the angiogenic process, make leukocyte-vascular interactions prime targets for therapeutics to potentially treat a wide range of diseases, including pathological and dysfunctional vessel growth, chronic inflammation and fibrosis. In this Review, we discuss how the different cell types that are present in and around microvessels interact, cooperate and instruct each other, and in this context we highlight drug targets as well as emerging druggable processes that can be exploited to restore tissue homeostasis.

Place, publisher, year, edition, pages
2016. Vol. 15, no 2, 125-142 p.
National Category
Medical Biotechnology
Identifiers
URN: urn:nbn:se:uu:diva-272649DOI: 10.1038/nrd.2015.2ISI: 000369182100014PubMedID: 26612664OAI: oai:DiVA.org:uu-272649DiVA: diva2:894493
Funder
Swedish Cancer SocietyRagnar Söderbergs stiftelseKnut and Alice Wallenberg Foundation
Available from: 2016-01-15 Created: 2016-01-15 Last updated: 2017-11-30Bibliographically approved

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Kreuger, JohanPhillipson, Mia

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