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Identification of Aminopyrimidine Regioisomers via Line Broadening Effects in 1H and 13C NMR Spectroscopy
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2004 (English)In: Australian Journal of Chemistry, Vol. 57, no 11, 1079-1083 p.Article in journal (Refereed) PublishedText
Abstract [en]

Substituted mono- and diamino-pyrimidines were synthesized as part of our medicinal chemistry programmes. Primary amines substituted at the 4-position exhibited room-temperature line broadening effects in both 1H and 13C NMR spectroscopy due to the presence of rotamers, but these effects were not observed for substituents in the 2-position. This provided a simple diagnostic tool for the identification of regioisomers, a determination which would otherwise have required two-dimensional experiments.

Place, publisher, year, edition, pages
2004. Vol. 57, no 11, 1079-1083 p.
National Category
Organic Chemistry
URN: urn:nbn:se:uu:diva-272672OAI: oai:DiVA.org:uu-272672DiVA: diva2:894580
Available from: 2016-01-15 Created: 2016-01-15 Last updated: 2016-01-15

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Odell, L.R.
Organic Chemistry

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