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Microwave-assisted synthesis of anti-tuberculosis, HIV and hepatitis C agents
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Division of Molecular Imaging.
University of Newcastle, Australia.
2014 (English)In: Microwaves in Drug Discovery and Development: Recent Advances, Future Medicine , 2014, 34-54 p.Chapter in book (Refereed)
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Text
Abstract [en]

Microwave heating technology is ideally suited to small-scale discovery chemistry applications, as it allows for full reaction control, rapid (super)heating, short reaction times, high safety and rapid feedback. These unique properties offer unparalleled opportunities for medicinal chemists to speed up the lead optimization process in early drug discovery. To illustrate these advantages, we herein describe a number of recent applications of dedicated microwave instrumentation in the synthesis of small molecules targeting three of the most prevalent infectious diseases: tuberculosis, HIV/AIDS and hepatitis C.

Place, publisher, year, edition, pages
Future Medicine , 2014. 34-54 p.
Series
Future Science Book Series
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Organic Chemistry
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URN: urn:nbn:se:uu:diva-272675DOI: 10.4155/fseb2013.13.19ISBN: 9781910419298 (print)ISBN: 9781910419311 (print)OAI: oai:DiVA.org:uu-272675DiVA: diva2:894584
Available from: 2016-01-15 Created: 2016-01-15 Last updated: 2016-11-24Bibliographically approved

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Gising, JohanLarhed, MatsOdell, Luke R

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