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Celiac Disease Does Not Influence Fracture Risk in Young Patients with Type 1 Diabetes
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
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2016 (English)In: Journal of Pediatrics, ISSN 0022-3476, E-ISSN 1097-6833, Vol. 169, 49-54 p.Article in journal (Refereed) Published
Abstract [en]


To examine the risk of any fractures in patients with both type 1 diabetes (T1D) and celiac disease (CD) vs patients with T1D only.


We performed a population-based cohort study. We defined T1D as individuals aged ≤30 years who had a diagnosis of diabetes recorded in the Swedish National Patient Register between 1964 and 2009. Individuals with CD were identified through biopsy report data between 1969 and 2008 from any of Sweden's 28 pathology departments. Some 958 individuals had both T1D and CD and were matched for sex, age, and calendar period with 4598 reference individuals with T1D only. We then used a stratified Cox regression analysis, where CD was modeled as a time-dependent covariate, to estimate the risk of any fractures and osteoporotic fractures (hip, distal forearm, thoracic and lumbar spine, and proximal humerus) in patients with both T1D and CD compared with that in patients with T1D only.


During follow-up, 12 patients with T1D and CD had a fracture (1 osteoporotic fracture). CD did not influence the risk of any fracture (adjusted hazard ratio = 0.77; 95% CI = 0.42-1.41) or osteoporotic fractures (adjusted hazard ratio = 0.46; 95% CI = 0.06-3.51) in patients with T1D. Stratification for time since CD diagnosis did not affect risk estimates.


Having a diagnosis of CD does not seem to influence fracture risk in young patients with T1D. Follow-up in this study was, however, too short to ascertain osteoporotic fractures which traditionally occur in old age.

Place, publisher, year, edition, pages
2016. Vol. 169, 49-54 p.
National Category
Clinical Medicine Pediatrics
URN: urn:nbn:se:uu:diva-273545DOI: 10.1016/j.jpeds.2015.10.032ISI: 000368595300013PubMedID: 26589343OAI: oai:DiVA.org:uu-273545DiVA: diva2:894796
NIH (National Institute of Health), UL1 TR000040Swedish Research Council
Available from: 2016-01-15 Created: 2016-01-15 Last updated: 2016-03-02Bibliographically approved

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