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Common and Diverging Integrin Signals Downstreamof Adhesion and Mechanical Stimuli and TheirInterplay with Reactive Oxygen Species
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. (Staffan Johansson)
2014 (English)In: Biophysical Reviews and Letters, ISSN 1793-0480, Vol. 9, no 2, 159-171 p.Article in journal (Refereed) Published
Abstract [en]

The integrin family of adhesion receptors regulates basic functions of cells, and the signalsthey induce are altered in tumor cells. In this review we discuss how different integrindependentsignals are generated during cell adhesion and by physical forces acting oncells.We also describe how reactive oxygen species are integral parts of integrin signalingand highlight a few important questions in the field. Answers to those may improve ourunderstanding of integrins and their role in the development of cancer.

Place, publisher, year, edition, pages
2014. Vol. 9, no 2, 159-171 p.
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Cell and Molecular Biology
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URN: urn:nbn:se:uu:diva-273702DOI: 10.1142/S1793048014300011OAI: oai:DiVA.org:uu-273702DiVA: diva2:894942
Available from: 2016-01-17 Created: 2016-01-17 Last updated: 2017-11-30Bibliographically approved

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fulltext(362 kB)145 downloads
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