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Insulin-like growth factor binding protein-3 predicts survival from acute childhood leukemia
Department of Hygiene and Epidemiology, Athens University Medical School .ORCID iD: 0000-0002-4935-7532
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2001 (English)In: Oncology, ISSN 0030-2414, E-ISSN 1423-0232, Vol. 60, no 3, p. 252-257Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE:

To investigate whether the three principal components of the insulin-like growth factor (IGF) system, IGF-1, IGF-2 and IGF binding protein-3 (IGFBP-3), are associated with survival from childhood leukemia.

PATIENTS AND METHODS:

116 children, 0--14 years old, with newly diagnosed and bone-marrow-biopsy-confirmed acute childhood leukemia between 1993 and 1996 were followed up until death or March 31, 1998. IGF-1, IGF-2 and IGFBP-3 were measured at diagnosis and clinical data, including presence of hepatosplenomegaly and number of white blood cells, were available.

RESULTS:

After controlling for gender, age, indicators of clinical severity and the other measured components of the IGF system there was a statistically significant (p < 0.05) inverse association of IGFBP-3 with survival. An increment of one standard deviation in IGFBP-3 was associated with a 65% reduction of the death hazard among the children with leukemia. Neither IGF-1 nor IGF-2 was associated with survival in this data set.

CONCLUSION:

The presented empirical evidence in conjunction with the fact that IGFBP-3 modulates IGF-1 and IGF-2 bioavailability and is likely to have proapoptotic effects makes this compound a plausible independent predictor of survival from childhood leukemia.

Place, publisher, year, edition, pages
2001. Vol. 60, no 3, p. 252-257
National Category
Pediatrics
Identifiers
URN: urn:nbn:se:uu:diva-273980DOI: 10.1159/000055326PubMedID: 11340377OAI: oai:DiVA.org:uu-273980DiVA, id: diva2:895680
Available from: 2016-01-19 Created: 2016-01-19 Last updated: 2017-11-30Bibliographically approved

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