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Mapping out the use of metformin among newly diagnosed type II diabetics in Uppsala County
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
2016 (English)Independent thesis Advanced level (degree of Master (One Year)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Introduction: Diabetes Mellitus type II is a condition of chronic hyperglycaemia and is presented by reduced insulin sensitivity. Tight glycaemic control decreases the risk for macro- and microvascular complications, hence the importance of providing treatment early. Metformin is considered the pharmacological first-hand choice due to its potency to lower blood glucose and beneficial effects on several diabetes complications. Aim:  To examine to which extent metformin is prescribed among newly diagnosed type II diabetics in Uppsala county and describe its effectiveness in this patient group. Materials and Methods:  The study population was divided into two groups based on if DM II treatment with metformin had been initiated or not during the study period of 12 months. Patient characteristics and data was retrospectively collected through electronic health records (Cosmic®). Results:  The study included 299 patients. Among these, 183 patients had been prescribed metformin for at least parts of the period while 116 patients had not. A patient group with a high average HbA1c value at diagnosis generally received metformin in monotherapy or in combination with other antidiabetics. Another group of patients with an initial average HbA1c value in the lower range was generally on diet treatment. An adequate reduction in HbA1c was observed for most of the patients. A majority of patients treated with metformin received an appropriate dose, but 20 % without metformin could very well have received it based on selected relevant health parameters. Conclusions: A degree of restrictiveness with prescribing metformin was observed, but the drug appeared to be appropriately prescribed based on the reduction in HbA1c values within the population.

Place, publisher, year, edition, pages
2016. , 31 p.
Keyword [en]
diabetes type II, prescribing, metformin
National Category
Social and Clinical Pharmacy
URN: urn:nbn:se:uu:diva-274193OAI: oai:DiVA.org:uu-274193DiVA: diva2:895933
Educational program
Master of Science Programme in Pharmacy
Available from: 2016-01-20 Created: 2016-01-20 Last updated: 2016-01-20Bibliographically approved

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