Initial evaluation of a new concept of treatment with levodopa/carbidopa microtablets for Parkinson’s disease
Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
Introduction: Parkinson’s disease (PD) is a neurodegenerative disease which leads to impaired motor control. Levodopa is the most widely used drug against the symptoms of PD. The effect is initially very good but with time the therapeutic window narrows, often leading to motor fluctuations and dyskinesia. To facilitate fine tuning of levodopa doses, a new concept of treatment with microtablets (5 mg levodopa, 1.25 mg carbidopa) distributed with an automatic dose dispenser has been developed. Aim: To evaluate the treatment with microtablets and the automatic dose dispenser with respect to effect and usability. Materials and Methods: A review of patient records was done. Questionnaires for the patients and their next of kin concerning the effect and usability were sent to patients. A Parkinson KinetiGraph™ (PKG) and a patient diary was used to assess the OFF, ON and dyskinesia periods. Reports from the dose dispensers were used to analyze compliance. Results: Eleven patients were included in the study. The effect of PD treatment was considered to be improved by six of nine patients, according to the survey, and five of nine pateints, according to the patients records. However, the change in frequency, magnitude and/or duration varied among the different symptoms included in the survey. The usability was in general rated as good, but some improvements were sought for. Patients who performed the PKG measurements were in general more dyskinetic than bradykinetic and reported in the patient diary more time in ON than OFF. The four dose dispenser reports showed that the compliance to the daily levdopa dose was 97(±5)%. Conclusions: The experienced effect of treatment can, for some PD patients, be improved by the use of microtablets, and the dose dispenser is considered user-friendly. This indicates the new concept could be a suitable treatment option for patients with PD. Further studies performed with a larger study population and a prospective design are needed to confirm the results.
Place, publisher, year, edition, pages
2015. , 65 p.
Levodopa, Parkinson's disease, microtablet
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-274236OAI: oai:DiVA.org:uu-274236DiVA: diva2:896138
Subject / course
Master of Science Programme in Pharmacy
Hammarlund-Udenaes, Margareta, Professor