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Rapid and Efficient Conversion of (CO2)-C-11 to (CO)-C-11 through Silacarboxylic Acids: Applications in Pd-Mediated Carbonylations
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry.
Aarhus Univ, Interdisciplinary Nanosci Ctr iNANO, Carbon Dioxide Activat Ctr CADIAC, DK-8000 Aarhus C, Denmark.;Aarhus Univ, Dept Chem, DK-8000 Aarhus C, Denmark..
Aarhus Univ, Interdisciplinary Nanosci Ctr iNANO, Carbon Dioxide Activat Ctr CADIAC, DK-8000 Aarhus C, Denmark.;Aarhus Univ, Dept Chem, DK-8000 Aarhus C, Denmark..
Aarhus Univ, Interdisciplinary Nanosci Ctr iNANO, Carbon Dioxide Activat Ctr CADIAC, DK-8000 Aarhus C, Denmark.;Aarhus Univ, Dept Chem, DK-8000 Aarhus C, Denmark..
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2015 (English)In: Chemistry - A European Journal, ISSN 0947-6539, E-ISSN 1521-3765, Vol. 21, no 49, 17601-17604 p.Article in journal (Refereed) Published
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Abstract [en]

Herein, we present a new rapid, efficient, and low-cost radiosynthetic protocol for the conversion of (CO2)-C-11 to (CO)-C-11 and its subsequent application in Pd-mediated reactions of importance for PET applications. This room-temperature methodology, using readily available chemical reagents, is carried out in simple glass vials, thus eliminating the need for expensive and specialized high-temperature equipment to access (CO)-C-11. With this fast and near-quantitative conversion of (CO2)-C-11 into (CO)-C-11, aryl and heteroaryl iodides were easily converted into a broad selection of biologically active amides in radiochemical yields ranging from 29-84 %.

Place, publisher, year, edition, pages
2015. Vol. 21, no 49, 17601-17604 p.
Keyword [en]
carbon monoxide, carbon-11, carbon dioxide fixation, positron emission tomography, radiochemistry
National Category
Medicinal Chemistry
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URN: urn:nbn:se:uu:diva-274454DOI: 10.1002/chem.201503262ISI: 000367185700011PubMedID: 26492852OAI: oai:DiVA.org:uu-274454DiVA: diva2:896464
Available from: 2016-01-21 Created: 2016-01-21 Last updated: 2017-11-30Bibliographically approved

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Nordeman, PatrikLarhed, MatsAntoni, Gunnar

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