Rapid and Efficient Conversion of (CO2)-C-11 to (CO)-C-11 through Silacarboxylic Acids: Applications in Pd-Mediated Carbonylations
2015 (English)In: Chemistry - A European Journal, ISSN 0947-6539, E-ISSN 1521-3765, Vol. 21, no 49, 17601-17604 p.Article in journal (Refereed) PublishedText
Herein, we present a new rapid, efficient, and low-cost radiosynthetic protocol for the conversion of (CO2)-C-11 to (CO)-C-11 and its subsequent application in Pd-mediated reactions of importance for PET applications. This room-temperature methodology, using readily available chemical reagents, is carried out in simple glass vials, thus eliminating the need for expensive and specialized high-temperature equipment to access (CO)-C-11. With this fast and near-quantitative conversion of (CO2)-C-11 into (CO)-C-11, aryl and heteroaryl iodides were easily converted into a broad selection of biologically active amides in radiochemical yields ranging from 29-84 %.
Place, publisher, year, edition, pages
2015. Vol. 21, no 49, 17601-17604 p.
carbon monoxide, carbon-11, carbon dioxide fixation, positron emission tomography, radiochemistry
IdentifiersURN: urn:nbn:se:uu:diva-274454DOI: 10.1002/chem.201503262ISI: 000367185700011PubMedID: 26492852OAI: oai:DiVA.org:uu-274454DiVA: diva2:896464