uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Common Familial Effects on Ischemic Stroke and Myocardial Infarction: A Prospective Population-Based Cohort Study
Show others and affiliations
2014 (English)In: Frontiers in Cardiovascular Medicine, ISSN 1539-4565, E-ISSN 2296-701X, 1-10- p.Article in journal (Refereed) Published
Abstract [en]


Recent genome-wide association studies suggest some overlap of genetic determinants of ischemic stroke (IS) and myocardial infarction (MI). This study aimed to assess shared familial risk between IS and MI in a large, population-wide cohort study.


Study participants free of IS and MI and their affected siblings were extracted from the Swedish Hospital Discharge and Cause of Death Registers between 1987 and 2007, forming an exposed sib-pair. They were matched by birth year of both siblings and calendar period to up to five unexposed sib-pairs. Stratified Cox regression analyses were used to assess familial risk of MI and IS in those exposed to having a sibling with IS (n = 31,659) and MI (n = 62,766), respectively, compared to unexposed (n = 143,728 and 265,974).


The overall risk of MI when exposed to having a sibling with IS was statistically significantly increased (RR, 1.44; 95% CI, 1.34-1.55, p < 0.001) to a similar extent as risk of IS when exposed to having a sibling with MI (RR, 1.41; 95% CI, 1.32-1.50, p < 0.001). The familial risks were similar in full siblings for both groups (RR for MI, 1.46; 95% CI, 1.35-1.58, p < 0.001; and RR for IS, 1.40; 95% CI, 1.30-1.40, p < 0.001) and half siblings (RR for MI, 1.29; 95% CI, 1.05-1.59, p < 0.001; and RR for IS, 1.38; 95% CI, 1.16-1.65, p < 0.001).


This large, population-wide study indicates that there is considerable overlap of familial risk between IS and MI.

Place, publisher, year, edition, pages
2014. 1-10- p.
Keyword [en]
coronary heart disease; epidemiology; family history; heritability; ischemic stroke
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-274524DOI: 10.3389/fcvm.2014.00003.PubMedID: 26664855OAI: oai:DiVA.org:uu-274524DiVA: diva2:896730
Available from: 2016-01-22 Created: 2016-01-22 Last updated: 2016-01-25

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Ingelsson, Erik
By organisation
Science for Life Laboratory, SciLifeLab
In the same journal
Frontiers in Cardiovascular Medicine
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 23 hits
ReferencesLink to record
Permanent link

Direct link