uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Regulation of Instant Blood Mediated Infl ammatoryReaction (IBMIR) in Pancreatic Islet Xeno-Transplantation: Points for Therapeutic Interventions
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology. (Magnusson)ORCID iD: 0000-0003-1142-854X
Show others and affiliations
2015 (English)In: Immune Responses to Biosurfaces: Mechanisms and Therapeutic Interventions / [ed] John D. Lambris, Kristina N. Ekdahl, Daniel Ricklin, Bo Nilsson, Cham: Springer, 2015, 171-188 p.Chapter in book (Refereed)
Abstract [en]

Xeno-transplantation of pancreatic islets represents a promising therapeuticalternative for the treatment of type 1 diabetes mellitus. However, potentinnate immune responses induced shortly after the transplantation of donor islets tothe recipient, comprising the Instant Blood Mediated Immune Reaction (IBMIR),exert detrimental actions on islet graft function. The coagulation and complementcascades together with the leukocyte and platelet populations are the major playersin IBMIR. This innate immune attack affects dramatically islet integrity and leadsto signifi cant loss of function of the xenograft. In the present review, we focus on themechanisms contributing to IBMIR components and address therapeutic interventionapproaches to limit IBMIR by administering inhibitors in circulation, by coatingthe islet surface with inhibitors or by generating transgenic donor animals; theseapproaches could result in improved xenograft survival.

Place, publisher, year, edition, pages
Cham: Springer, 2015. 171-188 p.
Series
Advances in Experimental Medicine and Biology, ISSN 0065-2598 ; 865
National Category
Immunology in the medical area
Identifiers
URN: urn:nbn:se:uu:diva-274741DOI: 10.1007%2F978-3-319-18603-0_11PubMedID: 26306450ISBN: 978-3-319-18602-3 (print)ISBN: 978-3-319-18603-0 (print)OAI: oai:DiVA.org:uu-274741DiVA: diva2:897481
Conference
The First International Conference on Immune Response to Biosurfaces (September 27–October 2, 2014) in Chania, Greece.
Funder
EU, FP7, Seventh Framework Programme, 602699
Available from: 2016-01-25 Created: 2016-01-25 Last updated: 2016-02-09Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Authority records BETA

Magnusson, Peetra U.

Search in DiVA

By author/editor
Magnusson, Peetra U.
By organisation
Clinical Immunology
Immunology in the medical area

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
isbn
urn-nbn

Altmetric score

doi
pubmed
isbn
urn-nbn
Total: 444 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf