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Regulation of Instant Blood Mediated Infl ammatoryReaction (IBMIR) in Pancreatic Islet Xeno-Transplantation: Points for Therapeutic Interventions
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology. (Magnusson)ORCID iD: 0000-0003-1142-854X
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2015 (English)In: Immune Responses to Biosurfaces: Mechanisms and Therapeutic Interventions / [ed] John D. Lambris, Kristina N. Ekdahl, Daniel Ricklin, Bo Nilsson, Cham: Springer, 2015, 171-188 p.Chapter in book (Refereed)
Abstract [en]

Xeno-transplantation of pancreatic islets represents a promising therapeuticalternative for the treatment of type 1 diabetes mellitus. However, potentinnate immune responses induced shortly after the transplantation of donor islets tothe recipient, comprising the Instant Blood Mediated Immune Reaction (IBMIR),exert detrimental actions on islet graft function. The coagulation and complementcascades together with the leukocyte and platelet populations are the major playersin IBMIR. This innate immune attack affects dramatically islet integrity and leadsto signifi cant loss of function of the xenograft. In the present review, we focus on themechanisms contributing to IBMIR components and address therapeutic interventionapproaches to limit IBMIR by administering inhibitors in circulation, by coatingthe islet surface with inhibitors or by generating transgenic donor animals; theseapproaches could result in improved xenograft survival.

Place, publisher, year, edition, pages
Cham: Springer, 2015. 171-188 p.
, Advances in Experimental Medicine and Biology, ISSN 0065-2598 ; 865
National Category
Immunology in the medical area
URN: urn:nbn:se:uu:diva-274741DOI: 10.1007%2F978-3-319-18603-0_11PubMedID: 26306450ISBN: 978-3-319-18602-3ISBN: 978-3-319-18603-0OAI: oai:DiVA.org:uu-274741DiVA: diva2:897481
The First International Conference on Immune Response to Biosurfaces (September 27–October 2, 2014) in Chania, Greece.
EU, FP7, Seventh Framework Programme, 602699
Available from: 2016-01-25 Created: 2016-01-25 Last updated: 2016-02-09Bibliographically approved

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