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Role of pore size and morphology in musculo-skeletal tissue regeneration
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
2016 (English)In: Materials science & engineering. C, biomimetic materials, sensors and systems, ISSN 0928-4931, E-ISSN 1873-0191, Vol. 61, 922-939 p.Article, review/survey (Refereed) Published
Abstract [en]

Biomaterials in the form of scaffolds hold great promise in the regeneration of diseased tissues. The scaffolds stimulate cellular adhesion, proliferation and differentiation. While the scaffold composition will dictate their biocompatibility, their porosity plays a key role in allowing proper cell penetration, nutrient diffusion as well as bone ingrowth. Porous scaffolds are processed with the help of a wide variety of techniques. Designing scaffolds with the appropriate porosity is a complex issue since this may jeopardize other physico-chemical properties. From a macroscopic point of view, parameters such as the overall architecture, pore morphology, interconnectivity and pore size distribution, have unique roles in allowing bone ingrowth to take place. From a microscopic perspective, the adsorption and retention of proteins in the microporosities of the material will dictate the subsequent cell adhesion. Therefore, the microstructure of the substrate can determine cell proliferation as well as the expression of specific osteogenic genes. This review aims at discussing the effect of micro- and macroporosity on the physicochemical and biological properties of scaffolds for musculo-skeletal tissue regeneration.

Place, publisher, year, edition, pages
2016. Vol. 61, 922-939 p.
Keyword [en]
Microporosity; Macroporosity; Porosity; Pore size; Scaffold; Bone regeneration; Microstructure; Rapid prototyping
National Category
Biomaterials Science Engineering and Technology
Identifiers
URN: urn:nbn:se:uu:diva-274759DOI: 10.1016/j.msec.2015.12.087ISI: 000370303600107PubMedID: 26838923OAI: oai:DiVA.org:uu-274759DiVA: diva2:897520
Available from: 2016-01-25 Created: 2016-01-25 Last updated: 2017-11-30Bibliographically approved

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Mestres, Gemma

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