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Short and long-term survival after primary percutaneous coronary intervention in young patients with ST-elevation myocardial infarction
Univ Copenhagen, Rigshosp, Ctr Heart, Dept Cardiol, DK-1168 Copenhagen, Denmark..
Univ Copenhagen, Rigshosp, Ctr Heart, Dept Cardiol, DK-1168 Copenhagen, Denmark..
Univ Copenhagen, Rigshosp, Ctr Heart, Dept Cardiol, DK-1168 Copenhagen, Denmark..
Lund Univ, Skane Univ Hosp, Dept Cardiol, Malmo, Sweden..
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2016 (English)In: International Journal of Cardiology, ISSN 0167-5273, E-ISSN 1874-1754, Vol. 203, 697-701 p.Article in journal (Refereed) PublishedText
Abstract [en]

The long-term prognosis of patients with ST-elevation myocardial infarction (STEMI) aged 45 years or younger and differences according to gender have not been well characterized. Methods: We included 16,685 consecutive STEMI patients from 2003 to 2012 (67,992 patient-years follow-up) from the Eastern Danish Heart Registry and the Swedish Coronary Angiography and Angioplasty Registry who were treated with primary percutaneous coronary intervention (PCI). Results: We identified 1026 (6.2%) patients up to 45 years of age (mean age: 40.7 vs. 66.3 years, P < 0.001). Patients in the young group were predominantly men (79.7% vs. 71.9%) and smokers (71.2% vs. 44.2%, P < 0.001) but with a lower prevalence of hypertension (17.3% vs. 39.3%), hyperlipidemia (18.0% vs. 23.8%), diabetes (9.0% vs. 12.4%) and previous myocardial infarction (6.9% vs. 12.2%, all P < 0.001) compared with older patients. Young patients had a 0.8% annualmortality. During the follow-up period 6.3% of young patients died vs. 28.5% of older patients (P < 0.001). Both 30-day-mortality (adjusted hazard ratio [HR] = 0.26, 95% confidence interval [CI]: 0.12-0.54, P < 0.001) and mortality after 30 days and onwards (HR = 0.25, CI: 0.17-0.37, P < 0.001) were significantly lower in the young group. There was no difference in short-term (HR = 0.78, CI: 0.32-1.90, P = 0.59) or long-term (HR = 0.62, CI: 0.33-1.91, P = 0.59) mortality between women and men in the young group (HR = 0.79, CI: 0.21-1.80, P = 0.39). Conclusions: STEMI patients, aged 45 years or younger, have an excellent prognosis after treatment with primary PCI. Long-termannual survival is more than 99% in these patients. Young women with STEMI do not have a worse long-term prognosis than young men with STEMI.

Place, publisher, year, edition, pages
2016. Vol. 203, 697-701 p.
Keyword [en]
ST-segment elevation myocardial infarction, Young patients, Long-term mortality, Percutaneous coronary intervention
National Category
Cardiac and Cardiovascular Systems
URN: urn:nbn:se:uu:diva-274415DOI: 10.1016/j.ijcard.2015.09.012ISI: 000367007200183PubMedID: 26583845OAI: oai:DiVA.org:uu-274415DiVA: diva2:897561
Available from: 2016-01-26 Created: 2016-01-21 Last updated: 2016-01-26Bibliographically approved

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Lagerqvist, BoJames, Stefan
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