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Functionalised type-I collagen as a hydrogel building block for bio-orthogonal tissue engineering applications
Linkoping Univ, Integrat Regenerat Med Ctr IGEN, S-58183 Linkoping, Sweden.;Linkoping Univ, Dept Phys Chem & Biol IFM, Div Mol Phys, S-58183 Linkoping, Sweden..
Karolinska Inst, Integrat Regenerat Med Ctr IGEN, S-17177 Stockholm, Sweden.;Karolinska Inst, Swedish Med Nanosci Ctr, Dept Neurosci, S-17177 Stockholm, Sweden..
Univ Ottawa, Inst Heart, Div Cardiac Surg Res, Ottawa, ON, Canada.;Univ Ottawa, Fac Med, Dept Biochem Microbiol & Immunol, Ottawa, ON, Canada..
Linkoping Univ, Integrat Regenerat Med Ctr, S-58185 Linkoping, Sweden.;Linkoping Univ, Dept Clin & Expt Med IKE, S-58185 Linkoping, Sweden..
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2016 (English)In: Journal of materials chemistry. B, ISSN 2050-750X, E-ISSN 2050-7518, Vol. 4, no 2, 318-326 p.Article in journal (Refereed) Published
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Abstract [en]

In this study, we derivatized type I collagen without altering its triple helical conformation to allow for facile hydrogel formation via the Michael addition of thiols to methacrylates without the addition of other crosslinking agents. This method provides the flexibility needed for the fabrication of injectable hydrogels or pre-fabricated implantable scaffolds, using the same components by tuning the modulus from Pa to kPa. Enzymatic degradability of the hydrogels can also be easily fine-tuned by variation of the ratio and the type of the crosslinking component. The structural morphology reveals a lamellar structure mimicking native collagen fibrils. The versatility of this material is demonstrated by its use as a pre-fabricated substrate for culturing human corneal epithelial cells and as an injectable hydrogel for 3-D encapsulation of cardiac progenitor cells.

Place, publisher, year, edition, pages
2016. Vol. 4, no 2, 318-326 p.
National Category
Polymer Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-274914DOI: 10.1039/c5tb02035bISI: 000367335200016OAI: oai:DiVA.org:uu-274914DiVA: diva2:898171
Funder
Swedish Research Council, 621-2012-4286Swedish Research Council, 521-2012-5706
Available from: 2016-01-27 Created: 2016-01-26 Last updated: 2017-11-30Bibliographically approved

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Wang, ShujiangHilborn, Jöns

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