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Guidance for a personal target value of F(E)NO in allergic asthma: case report and theoretical example
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Respiratory Medicine and Allergology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Research and Development, Gävleborg. (Marieann Högman)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Respiratory Medicine and Allergology. (Marieann Högman)
2013 (English)In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 118, no 1, 59-61 p.Article in journal (Refereed) Published
Abstract [en]

In clinically stable asthma the exhaled NO values (FENO) are generally higher than in control subjects. Therefore, reference values are of limited importance in clinical practice. This is demonstrated in this case report, but it is also shown that NO parameters from non-linear modelling do have a clinical value. A subject with asthma was treated with inhaled corticosteroids for 1 week. The non-linear NO model was used to measure the response to treatment. The NO parameters from subjects with atopic rhinitis and asthma were fed into a computer program to generate theoretical FENO50 values, i.e. target values. There was a dramatic decrease in FENO50 due to treatment, from 82 to 34 ppb, but it remained higher than in healthy controls. This is due to the elevated diffusion rate of NO, unchanged by treatment. When the NO parameters are known, a personal best value of FENO50 (fractional concentration of exhaled NO in the gas phase, 50 mL/s) can be calculated, which can be the target value when only FENO50 can be monitored. In conclusion, reference values for NO parameters are shown to be clinically useful. It is essential that every patient receives his/her target value of FENO50, when only a single NO measurement is available. In our opinion, this is the reason why there are few successful studies of trying to target the NO value with inhaled corticosteroids. 

Place, publisher, year, edition, pages
2013. Vol. 118, no 1, 59-61 p.
Keyword [en]
Asthma, nitric oxide, treatment
National Category
Respiratory Medicine and Allergy
Research subject
Lung Medicine
Identifiers
URN: urn:nbn:se:uu:diva-275031DOI: 10.3109/03009734.2012.704433OAI: oai:DiVA.org:uu-275031DiVA: diva2:898490
Available from: 2016-01-28 Created: 2016-01-28 Last updated: 2017-11-30Bibliographically approved

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