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Biphalin protects against cognitive deficits in a mouse model of mild traumatic brain injury (mTBI)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. Polish Acad Sci, Dept Neuropeptides, Mossakowski Med Res Ctr, PL-02106 Warsaw, Poland..
Tel Aviv Univ, Dept Anat, Sackler Sch Med, IL-69978 Tel Aviv, Israel..
Polish Acad Sci, Dept Neuropeptides, Mossakowski Med Res Ctr, PL-02106 Warsaw, Poland.;Univ Warsaw, Fac Chem, PL-02093 Warsaw, Poland..
Polish Acad Sci, Dept Neuropeptides, Mossakowski Med Res Ctr, PL-02106 Warsaw, Poland..
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2016 (English)In: Neuropharmacology, ISSN 0028-3908, E-ISSN 1873-7064, Vol. 101, 506-518 p.Article in journal (Refereed) PublishedText
Abstract [en]

Traumatic brain injury (TBI) is often a result of traffic accidents, contact sports or battlefield explosions. A mild form of traumatic brain injury (mTBI) is frequently underestimated, as the immediate physical symptoms decrease rapidly and conventional neuroimaging studies often do not show visible evidence of brain lesions. However, cognitive impairments persist for weeks, months or even years after the incident. Endogenous opioids were documented to play a role in thmodulation of mTBI pathology, whereas exogenous opioids were shown to possess neuroprotective properties. In the present study, biphalin, a dimeric enkephalin analog, improved cognitive performance in the Morris Water Maze and Novel Object Recognition tests in a mouse weight-drop model of mTBI. The effect of a single systemic injection of 10 mg/kg biphalin immediately after trauma was reversed by naltrexone, suggesting an opioid receptor-mediated mechanism. Biphalin also reduced cortical and hippocampal neurodegeneration, as shown by silver staining. Our data indicates that opioid receptor activation by biphalin may provide neuroprotection of post-traumatic neurodegeneration processes and may protect against memory impairments.

Place, publisher, year, edition, pages
2016. Vol. 101, 506-518 p.
Keyword [en]
Neuroprotection, Biphalin, Traumatic brain injury, Mouse model
National Category
Neurology Pharmaceutical Sciences
URN: urn:nbn:se:uu:diva-274898DOI: 10.1016/j.neuropharm.2015.10.014ISI: 000367483800047OAI: oai:DiVA.org:uu-274898DiVA: diva2:899866
Available from: 2016-02-02 Created: 2016-01-26 Last updated: 2016-02-02Bibliographically approved

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Lesniak, Anna
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