Rapid fluorous Stille coupling reactions conducted under microwave irradiation
1997 (English)In: Journal of Organic Chemistry, ISSN 0022-3263, E-ISSN 1520-6904, Vol. 62, no 16, 5583-5587 p.Article in journal (Refereed) PublishedText
Palladium-catalyzed fluorous Stille cross-coupling reactions with organic halides or triflates require only 90-120 s for completion when conducted under microwave irradiation. Comparable thermal reactions require about 1 day. Fourteen different coupling products were synthesized and isolated in good yields after three-phase extraction (FC-84, dichloromethane, water) and chromatography. The examples extend the scope of the fluorous Stille coupling with respect to both the tin and halide/triflate components. Applications in parallel synthesis are suggested.
Place, publisher, year, edition, pages
UNIV PITTSBURGH,DEPT CHEM,PITTSBURGH,PA 15260. UNIV UPPSALA,CTR BIOMED,DEPT ORGAN PHARMACEUT CHEM,S-75123 UPPSALA,SWEDEN., 1997. Vol. 62, no 16, 5583-5587 p.
IdentifiersURN: urn:nbn:se:uu:diva-275395DOI: 10.1021/jo970362yISI: A1997XP91100048OAI: oai:DiVA.org:uu-275395DiVA: diva2:900243