High-speed Heck reactions in ionic liquid with controlled microwave heating
2002 (English)In: Journal of Organic Chemistry, ISSN 0022-3263, E-ISSN 1520-6904, Vol. 67, no 17, 6243-6246 p.Article in journal (Refereed) PublishedText
Palladium-catalyzed Heck arylations in the polar and robust ionic liquid, 1-butyl-3-methylimidazolium hexafluorophosphate (bmimPF(6)), have for the first time been accomplished under microwave irradiation. The couplings were efficiently performed in sealed tubes within 5-45 min of heating. Without significant reductions in yield, a phosphine-free ionic catalyst phase could be recycled in five successive 20 min reactions at 180 degreesC. The product was easily removed from the reaction medium by distillation.
Place, publisher, year, edition, pages
Uppsala Univ, BMC, Dept Organ Pharmaceut Chem, SE-75123 Uppsala, Sweden., 2002. Vol. 67, no 17, 6243-6246 p.
IdentifiersURN: urn:nbn:se:uu:diva-275417DOI: 10.1021/jo025942wISI: 000177559800058PubMedID: 12182671OAI: oai:DiVA.org:uu-275417DiVA: diva2:900282