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A rapid microwave protocol for Heck vinylation of aryl chlorides under air
Uppsala Univ, Dept Organ Pharmaceut Chem, Biomed Ctr, Uppsala, Sweden..
Uppsala Univ, Dept Organ Pharmaceut Chem, Biomed Ctr, Uppsala, Sweden..
Uppsala Univ, Dept Organ Pharmaceut Chem, Biomed Ctr, Uppsala, Sweden..
2003 (English)In: Molecular diversity, ISSN 1381-1991, E-ISSN 1573-501X, Vol. 7, no 2-4, 107-114 p.Article in journal (Refereed) Published
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Abstract [en]

In modern high-throughput chemistry, the overall workflow is a crucial factor and much work is devoted to speeding up the process of chemistry development. Since automated microwave-based synthesizers are known to streamline the compound production and to accelerate slow organic transformations, this technology was implemented for Heck reactions with sluggish aryl chlorides. Furthermore, homogeneous palladium-catalyzed Heck vinylations of aryl chlorides can be performed under air under optimized conditions. Based on this finding, controlled microwave heating was utilized to accelerate model reactions down to 30 min employing a mixture of ionic liquid and 1,4-dioxane as solvent.

Place, publisher, year, edition, pages
2003. Vol. 7, no 2-4, 107-114 p.
Keyword [en]
aryl chloride, Heck reaction, ionic liquid, microwave heating, palladium catalysis
National Category
Organic Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-275411DOI: 10.1023/B:MODI.0000006798.53091.a2ISI: 000207200600003PubMedID: 14870839OAI: oai:DiVA.org:uu-275411DiVA: diva2:900290
Available from: 2016-02-03 Created: 2016-02-03 Last updated: 2017-11-30

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