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Incidence of tonsillar cancer in northern Sweden: Impact of human papilloma virus
Umea Univ, Div Otorhinolaryngol, Dept Clin Sci, S-90185 Umea, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery. Umea Univ, Div Otorhinolaryngol, Dept Clin Sci, S-90185 Umea, Sweden..
Umea Univ, Div Oncol, Dept Radiat Sci, S-90185 Umea, Sweden..
Umea Univ, Div Oncol, Dept Radiat Sci, S-90185 Umea, Sweden..
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2015 (English)In: Oncology Letters, ISSN 1792-1074, E-ISSN 1792-1082, Vol. 10, no 6, 3565-3572 p.Article in journal (Refereed) Published
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Abstract [en]

The incidence rate of tonsillar cancer is increasing worldwide. The current study identifies a parallel increase in the incidence of tonsillar cancer, human papilloma virus (HPV) and p16 expression among a population from northern Sweden, a sparsely populated area, confirming the strong association between p16 and HPV infection in tonsillar tissue. Data from the Swedish Cancer Registry was assessed to identify cases of tonsillar cancer in the northern territorial area of Sweden. HPV DNA was extracted from paraffin embedded diagnostic biopsies and detected by polymerase chain reaction using general primers Gp5+/6+ and CpI/IIG. Expression of p16 was identified by immunochemistry. Patients were grouped into urban or rural residence categories. A total of 214 cases were identified, comprising 155 (72.4%) men and 59 (27.6%) women, and 65 of these patients, who presented between 2000 and 2012, were analyzed. The overall median age for the analyzed patients was 58 years; 48 (74%) were males (median age, 57.5 years) and 17 (26%) were females (median age, 65 years). Of the 65 specimens, 59 (91%) were positive for HPV, and 62 (95%) expressed p16. The incidence of tonsillar cancer in the cohort demonstrated a 2-fold increase between 1990 and 2013; specifically, a 2.7-fold increase was observed in men whilst the female group exhibited only a small increase. These findings demonstrate a strong association between p16 expression and HPV infection in tonsillar malignancies. The incidence of HPV-positive tonsillar cancer has increased in recent years, even in sparsely populated regions, as demonstrated in northern Sweden.

Place, publisher, year, edition, pages
2015. Vol. 10, no 6, 3565-3572 p.
Keyword [en]
head and neck cancer, human papilloma virus, immunohistochemistry, incidence, p16, tonsillar cancer
National Category
Otorhinolaryngology
Identifiers
URN: urn:nbn:se:uu:diva-275482DOI: 10.3892/ol.2015.3775ISI: 000367232600038OAI: oai:DiVA.org:uu-275482DiVA: diva2:900392
Available from: 2016-02-04 Created: 2016-02-04 Last updated: 2017-11-30Bibliographically approved

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