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Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation
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2015 (English)In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 6, 8658Article in journal (Refereed) Published
Abstract [en]

Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10(-8)) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.

Place, publisher, year, edition, pages
2015. Vol. 6, 8658
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URN: urn:nbn:se:uu:diva-275522DOI: 10.1038/ncomms9658ISI: 000367589100001PubMedID: 26635082OAI: oai:DiVA.org:uu-275522DiVA: diva2:900452
Swedish Foundation for Strategic Research , ICA08-0047Swedish Research Council, 2012-1397Swedish Heart Lung Foundation, 20120197Swedish Society of MedicineEU, FP7, Seventh Framework ProgrammeWellcome trustSwedish National Infrastructure for Computing (SNIC), b2013056
Available from: 2016-02-04 Created: 2016-02-04 Last updated: 2016-05-10Bibliographically approved

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Enroth, StefanIngelsson, ErikJohansson, ÅsaLind, LarsGyllensten, Ulf
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Medicinsk genetik och genomikScience for Life Laboratory, SciLifeLabMolecular epidemiologyUCR-Uppsala Clinical Research CenterCardiovascular epidemiology
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