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Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation
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2015 (English)In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 6, 8658Article in journal (Refereed) Published
Abstract [en]

Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10(-8)) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.

Place, publisher, year, edition, pages
2015. Vol. 6, 8658
National Category
Genetics
Identifiers
URN: urn:nbn:se:uu:diva-275522DOI: 10.1038/ncomms9658ISI: 000367589100001PubMedID: 26635082OAI: oai:DiVA.org:uu-275522DiVA: diva2:900452
Funder
Swedish Foundation for Strategic Research , ICA08-0047Swedish Research Council, 2012-1397Swedish Heart Lung Foundation, 20120197Swedish Society of MedicineEU, FP7, Seventh Framework ProgrammeWellcome trustSwedish National Infrastructure for Computing (SNIC), b2013056
Available from: 2016-02-04 Created: 2016-02-04 Last updated: 2017-11-30Bibliographically approved

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Enroth, StefanIngelsson, ErikJohansson, ÅsaLind, LarsGyllensten, Ulf

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Medicinsk genetik och genomikScience for Life Laboratory, SciLifeLabMolecular epidemiologyUCR-Uppsala Clinical Research CenterCardiovascular epidemiology
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