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Genetical Genomics of Behavior: A Novel Chicken Genomic Model for Anxiety Behavior
Linkoping Univ, AVIAN Behav Genom & Physiol Grp, IFM Biol, S-58183 Linkoping, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology. Uppsala Univ, Inst Neurovetenskap, S-75125 Uppsala, Sweden..
Linkoping Univ, AVIAN Behav Genom & Physiol Grp, IFM Biol, S-58183 Linkoping, Sweden..
Linkoping Univ, AVIAN Behav Genom & Physiol Grp, IFM Biol, S-58183 Linkoping, Sweden..
2016 (English)In: Genetics, ISSN 0016-6731, E-ISSN 1943-2631, Vol. 202, no 1, 327-+ p.Article in journal (Refereed) Published
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Abstract [en]

The identification of genetic variants responsible for behavioral variation is an enduring goal in biology, with wide-scale ramifications, ranging from medical research to evolutionary theory on personality syndromes. Here, we use for the first time a large-scale genetical genomics analysis in the brains of chickens to identify genes affecting anxiety as measured by an open field test. We combine quantitative trait locus (QTL) analysis in 572 individuals and expression QTL (eQTL) analysis in 129 individuals from an advanced intercross between domestic chickens and Red Junglefowl. We identify 10 putative quantitative trait genes affecting anxiety behavior. These genes were tested for an association in the mouse Heterogeneous Stock anxiety (open field) data set and human GWAS data sets for bipolar disorder, major depressive disorder, and schizophrenia. Although comparisons between species are complex, associations were observed for four of the candidate genes in mice and three of the candidate genes in humans. Using a multimodel approach we have therefore identified a number of putative quantitative trait genes affecting anxiety behavior, principally in chickens but also with some potentially translational effects as well. This study demonstrates that chickens are an excellent model organism for the genetic dissection of behavior.

Place, publisher, year, edition, pages
2016. Vol. 202, no 1, 327-+ p.
Keyword [en]
anxiety, behavioral genes, eQTL, QTL, causal genes, personality
National Category
Medical Genetics
Identifiers
URN: urn:nbn:se:uu:diva-275565DOI: 10.1534/genetics.115.179010ISI: 000367718100026PubMedID: 26733665OAI: oai:DiVA.org:uu-275565DiVA: diva2:900472
Funder
Swedish Research CouncilEU, European Research Council, GENEWELL 322206
Available from: 2016-02-04 Created: 2016-02-04 Last updated: 2017-11-30Bibliographically approved

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Williams, Michael J.

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