Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes
2011 (English)In: Nat Genet, Vol. 43, no 6, 561-4 p.Article in journal (Refereed) Published
Genome-wide association studies have identified many genetic variants associated with complex traits. However, at only a minority of loci have the molecular mechanisms mediating these associations been characterized. In parallel, whereas cis regulatory patterns of gene expression have been extensively explored, the identification of trans regulatory effects in humans has attracted less attention. Here we show that the type 2 diabetes and high-density lipoprotein cholesterol-associated cis-acting expression quantitative trait locus (eQTL) of the maternally expressed transcription factor KLF14 acts as a master trans regulator of adipose gene expression. Expression levels of genes regulated by this trans-eQTL are highly correlated with concurrently measured metabolic traits, and a subset of the trans-regulated genes harbor variants directly associated with metabolic phenotypes. This trans-eQTL network provides a mechanistic understanding of the effect of the KLF14 locus on metabolic disease risk and offers a potential model for other complex traits.
Place, publisher, year, edition, pages
2011. Vol. 43, no 6, 561-4 p.
Adipose Tissue/*metabolism, Cholesterol, HDL/*genetics, Diabetes Mellitus, Type 2/*genetics, Female, *Gene Expression Regulation, Genome-Wide Association Study, *Genomic Imprinting, Humans, Phenotype, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Sp Transcription Factors/*genetics
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-275653ISBN: 1546-1718 (Electronic) 1061-4036 (Linking)OAI: oai:DiVA.org:uu-275653DiVA: diva2:900620
Small, Kerrin S Hedman, Asa K Grundberg, Elin Nica, Alexandra C Thorleifsson, Gudmar Kong, Augustine Thorsteindottir, Unnur Shin, So-Youn Richards, Hannah B GIANT Consortium MAGIC Investigators DIAGRAM Consortium Soranzo, Nicole Ahmadi, Kourosh R Lindgren, Cecilia M Stefansson, Kari Dermitzakis, Emmanouil T Deloukas, Panos Spector, Timothy D McCarthy, Mark I MuTHER Consortium 081917/Wellcome Trust/United Kingdom R01 MH090941/MH/NIMH NIH HHS/United States Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't United States Nature genetics Nat Genet. 2011 Jun;43(6):561-4. doi: 10.1038/ng.833. Epub 2011 May 15.2016-02-042016-02-042016-02-05