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Anisotropic Membrane Curvature Sensing by Amphipathic Peptides
Stockholm Univ, Dept Biochem & Biophys, Ctr Biomembrane Res, S-10691 Stockholm, Sweden..
Stockholm Univ, Dept Biochem & Biophys, Ctr Biomembrane Res, S-10691 Stockholm, Sweden..
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology.
2016 (English)In: Biophysical Journal, ISSN 0006-3495, E-ISSN 1542-0086, Vol. 110, no 1, 197-204 p.Article in journal (Refereed) PublishedText
Abstract [en]

Many proteins and peptides have an intrinsic capacity to sense and induce membrane curvature, and play crucial roles for organizing and remodeling cell membranes. However, the molecular driving forces behind these processes are not well understood. Here, we describe an approach to study curvature sensing by simulating the interactions of single molecules with a buckled lipid bilayer. We analyze three amphipathic antimicrobial peptides, a class of membrane-associated molecules that specifically target and destabilize bacterial membranes, and find qualitatively different sensing characteristics that would be difficult to resolve with other methods. Our findings provide evidence for direction-dependent curvature sensing mechanisms in amphipathic peptides and challenge existing theories of hydrophobic insertion. The buckling approach is generally applicable to a wide range of curvature-sensing molecules, and our results provide strong motivation to develop new experimental methods to track position and orientation of membrane proteins.

Place, publisher, year, edition, pages
2016. Vol. 110, no 1, 197-204 p.
National Category
URN: urn:nbn:se:uu:diva-275546DOI: 10.1016/j.bpj.2015.11.3512ISI: 000367783900012PubMedID: 26745422OAI: oai:DiVA.org:uu-275546DiVA: diva2:900639
Wenner-Gren FoundationsSwedish Foundation for Strategic Research Swedish National Infrastructure for Computing (SNIC), SNIC 2014/1-236
Available from: 2016-02-04 Created: 2016-02-04 Last updated: 2016-06-16

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