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Swedish National Penile Cancer Register: incidence, tumour characteristics, management and survival
Orebro Univ Hosp, Dept Urol, SE-70185 Orebro, Sweden..
Umea Univ, Dept Surg & Perioperat Sci, Urol & Androl, Umea, Sweden..
Umea Univ, Dept Surg & Perioperat Sci, Urol & Androl, Umea, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden..
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2016 (English)In: BJU International, ISSN 1464-4096, E-ISSN 1464-410X, Vol. 117, no 2, 287-292 p.Article in journal (Refereed) PublishedText
Abstract [en]

Objectives To assess penile cancer incidence, stage distribution, adherence to guidelines and prognostic factors in a population-based setting. Patients and Methods The population-based Swedish National Penile Cancer Register (NPECR) contains detailed information on tumour characteristics and management patterns. A total of 1 678 men with primary squamous cell carcinoma of the penis identified in the NPECR between 2000 and 2012 were included in the study. Results The mean age-adjusted incidence of penile cancer was 2.1/100 000 men, remaining virtually unchanged during the study period. At diagnosis, 14 and 2% of the men had clinical N+ and M+ disease, respectively. Most men were staged pTis (34%), pT2 (19%), or pT1 (18%), while stage information was unavailable for 18% of the men. Organ-preserving treatment was used in 71% of Tis-T1 tumours. Of men with cN0 and >= pT1G2 disease, 50% underwent lymph node staging, while 74% of men with cN1-3 disease underwent lymph node dissection. The overall 5-year relative survival rate was 82%. Men aged >= 40 years and those with pT2-3, G2-3 and N+ tumours had worse outcomes. Conclusions The incidence of penile cancer in Sweden is stable. Most men presented with localized disease, and the proportion of non-invasive tumours was high. During the period under study, adherence to guidelines was suboptimum. The overall 5-year relative survival rate was 82%. Older age, increasing tumour stage and grade, and increasing lymph node stage were associated with poorer survival.

Place, publisher, year, edition, pages
2016. Vol. 117, no 2, 287-292 p.
Keyword [en]
penile cancer, population-based, incidence, TNM, prognostic factors, survival
National Category
Cancer and Oncology Urology and Nephrology
URN: urn:nbn:se:uu:diva-275531DOI: 10.1111/bju.12993ISI: 000367717300018PubMedID: 25395083OAI: oai:DiVA.org:uu-275531DiVA: diva2:901719
Available from: 2016-02-09 Created: 2016-02-04 Last updated: 2016-02-09Bibliographically approved

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