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Ambient carbon monoxide associated with alleviated respiratory inflammation in healthy young adults
Fudan Univ, Minist Educ, Key Lab Publ Hlth Safety, Sch Publ Hlth,Minist Hlth,Key Lab Hlth Technol As, Shanghai 200433, Peoples R China..
Fudan Univ, Minist Educ, Key Lab Publ Hlth Safety, Sch Publ Hlth,Minist Hlth,Key Lab Hlth Technol As, Shanghai 200433, Peoples R China.;Fudan Univ, Shanghai Key Lab Atmospher Particle Pollut & Prev, Shanghai 200433, Peoples R China..
Fudan Univ, Minist Educ, Key Lab Publ Hlth Safety, Sch Publ Hlth,Minist Hlth,Key Lab Hlth Technol As, Shanghai 200433, Peoples R China..
Fudan Univ, Minist Educ, Key Lab Publ Hlth Safety, Sch Publ Hlth,Minist Hlth,Key Lab Hlth Technol As, Shanghai 200433, Peoples R China.;Fudan Univ, Shanghai Key Lab Atmospher Particle Pollut & Prev, Shanghai 200433, Peoples R China..
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2016 (English)In: Environmental Pollution, ISSN 0269-7491, E-ISSN 1873-6424, Vol. 208, 294-298 p.Article in journal (Refereed) Published
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Abstract [en]

There is increasing controversy on whether acute exposure to ambient carbon monoxide (CO) is hazardous on respiratory health. We therefore performed a longitudinal panel study to evaluate the acute effects of ambient CO on fractional exhaled nitric oxide (FeNO), a well-established biomarker of airway inflammation. We completed 4-6 rounds of health examinations among 75 healthy young adults during April to June in 2013 in Shanghai, China. We applied the linear mixed-effect model to investigate the short-term associations between CO and FeNO. CO exposure during 2-72 h preceding health tests was significantly associated with decreased FeNO levels. For example, an interquartile range increase (0.3 mg/m(3)) of 2-h CO exposure corresponded to 10.6% decrease in FeNO. This association remained when controlling for the concomitant exposure to co-pollutants. This study provided support that short-term exposure to ambient CO might be related with reduced levels of FeNO, a biomarker of lower airway inflammation.

Place, publisher, year, edition, pages
2016. Vol. 208, 294-298 p.
Keyword [en]
Air pollution, Carbon monoxide, Respiratory inflammation, Panel study
National Category
Ecology Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:uu:diva-276832DOI: 10.1016/j.envpol.2015.07.029ISI: 000368306400035OAI: oai:DiVA.org:uu-276832DiVA: diva2:903485
Available from: 2016-02-16 Created: 2016-02-16 Last updated: 2017-11-30Bibliographically approved

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Norbäck, Dan

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