Complement Activation Correlates With Disease Severity and Contributes to Cytokine Responses in Plasmodium falciparum Malaria
2015 (English)In: The Internet Journal of Infectious Diseases, ISSN 1528-8366, Vol. 212, no 11, 1835-1840 p.Article in journal (Refereed) Published
The impact of complement activation and its possible relation to cytokine responses during malaria pathology was investigated in plasma samples from patients with confirmed Plasmodium falciparum malaria and in human whole-blood specimens stimulated with malaria-relevant agents ex vivo. Complement was significantly activated in the malaria cohort, compared with healthy controls, and was positively correlated with disease severity and with certain cytokines, in particular interleukin 8 (IL-8)/CXCL8. This was confirmed in ex vivo-stimulated blood specimens, in which complement inhibition significantly reduced IL-8/CXCL8 release. P. falciparum malaria is associated with systemic complement activation and complement-dependent release of inflammatory cytokines, of which IL-8/CXCL8 is particularly prominent.
Place, publisher, year, edition, pages
2015. Vol. 212, no 11, 1835-1840 p.
C5a/C5aR1; IL-8/CXCL8; Plasmodium falciparum; complement activation; cytokines; heme; hemozoin; inflammation; malaria
Medical and Health Sciences Immunology in the medical area
IdentifiersURN: urn:nbn:se:uu:diva-276987DOI: 10.1093/infdis/jiv283ISI: 000368669500019PubMedID: 25980034OAI: oai:DiVA.org:uu-276987DiVA: diva2:903800
FunderEU, FP7, Seventh Framework Programme