Separation of two labeled components of [111In] -OctreoScan by HPLC
2001 (English)In: Journal of Radioanalytical and Nuclear Chemistry, ISSN 0236-5731, E-ISSN 1588-2780, Vol. 247, no 1, 95-99 p.Article in journal (Refereed) Published
[111In]-DTPA-D-Phe1-octreotide (OctreoScan®, Mallinkrodt) is widely used for detection of neuroendocrine tumors and has lately been proposed for radionuclide therapy. We found, using HPLC and a GF-250 column (Zorbax®, Hewlett Packard), that OctreoScan® can be separated in two radiolabeled components of about equal amount. The analytical conditions for a quantitative isolation indicate that the two-peptide components of OctreoScan®have different lipophilicity. The isolated components are stable and do not transform into each other at room temperature during 6 hours (shelf-life of OctreoScan®).
Place, publisher, year, edition, pages
2001. Vol. 247, no 1, 95-99 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-62498DOI: 10.1023/A:1006715114925OAI: oai:DiVA.org:uu-62498DiVA: diva2:90409