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Separation of two labeled components of [111In] -OctreoScan by HPLC
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Biomedical Radiation Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Biomedical Radiation Sciences.
2001 (English)In: Journal of Radioanalytical and Nuclear Chemistry, ISSN 0236-5731, E-ISSN 1588-2780, Vol. 247, no 1, 95-99 p.Article in journal (Refereed) Published
Abstract [en]

[111In]-DTPA-D-Phe1-octreotide (OctreoScan®, Mallinkrodt) is widely used for detection of neuroendocrine tumors and has lately been proposed for radionuclide therapy. We found, using HPLC and a GF-250 column (Zorbax®, Hewlett Packard), that OctreoScan® can be separated in two radiolabeled components of about equal amount. The analytical conditions for a quantitative isolation indicate that the two-peptide components of OctreoScan®have different lipophilicity. The isolated components are stable and do not transform into each other at room temperature during 6 hours (shelf-life of OctreoScan®).

Place, publisher, year, edition, pages
2001. Vol. 247, no 1, 95-99 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-62498DOI: 10.1023/A:1006715114925OAI: oai:DiVA.org:uu-62498DiVA: diva2:90409
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2017-11-30Bibliographically approved

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Tolmachev, Vladimir

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Biomedical Radiation SciencesDepartment of Oncology, Radiology and Clinical Immunology
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