Radiobromination of closo-dodecaborate anion. Aspects of labelling chemistry in aqueous solutions using Chloramine-T
2002 (English)In: Radiochimica Acta, ISSN 0033-8230, Vol. 90, no 4, 229-235 p.Article in journal (Refereed) Published
Closo-dodecaborate dianion is a three-dimensional aromatic inorganic molecule, which can be easily halogenated forming a stable halogen-boron bond. Derivatives of closo-dodecaborate were considered as a convenient chemical form of delivery of enriched 10B to malignant tumors for boron neutron capture therapy (BNCT). Some properties of closo-dodecaborate (hydrophilicity, strength of halogen-boron bond, charge at lysosomal pH) make it attractive as a potential prosthetic group for attachment of radioactive halogens to tumor-targeting proteins. Bromine radioisotopes possess a variety of useful nuclear characteristics, and can be used in different areas of clinical diagnostics and therapy. In this work, a basic chemistry of closo-dodecaborate radiobromination was studied. It was found, that di(triethylamonium) dodecahydro-closo-dodecaborate can be labelled in high yield, more then 90%, in a wide pH range. By decreasing the pH, the bromination can be directed to closo-dodecaborate in the presence of phenolic compounds. The results of the study indicate a possibility of using the radioactive bromine label for investigation of pharmacokinetics of boronated compounds for BNCT.
Place, publisher, year, edition, pages
2002. Vol. 90, no 4, 229-235 p.
IdentifiersURN: urn:nbn:se:uu:diva-62500OAI: oai:DiVA.org:uu-62500DiVA: diva2:90411