Nociceptin/orphanin FQ into the rat periaqueductal gray decreases the withdrawal latency to heat and loading, an effect reversed by (Nphe1)nociceptin(1-13)NH2
2001 (English)In: Brain Research, ISSN 0006-8993, E-ISSN 1872-6240, Vol. 922, no 1, 118-124 p.Article in journal (Refereed) Published
The present study investigated the effect of intraperiaqueductal grey injection of nociceptin/orphanin FQ (N/OFQ) and an antagonist (Nphe(1))nociceptin(1-13)NH(2) on the hindpaw withdrawal response to thermal and mechanical stimulation in rats. N/OFQ (5 nmol) significantly decreased the nociceptive thresholds in both tests and 1, 5 and 10 nmol of (Nphe(1))nociceptin(1-13)NH(2) significantly reversed this effect in a dose dependent way. Our results demonstrate, that N/OFQ has a nociceptive action, possibly through inhibition of PAG neurons. This effect is blocked by the antagonist (Nphe(1))nociceptin(1-13)NH(2) probably via ORL1 receptors in the periaqueductal grey.
Place, publisher, year, edition, pages
2001. Vol. 922, no 1, 118-124 p.
nociceptin, nociceptin antagonist, nociception, ORL-1 receptor, periaqueductal grey
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-62592DOI: 10.1016/S0006-8993(01)03161-4ISI: 000172864300014PubMedID: 11730709OAI: oai:DiVA.org:uu-62592DiVA: diva2:90503