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Nociceptin/orphanin FQ tissue concentration in the rat brain: Effects of repeated ethanol administration at various post-treatment intervals
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. (Pharmacology)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. (Pharmacology)
2002 (English)In: Progress in Neuro-psychopharmacology and Biological Psychiatry, ISSN 0278-5846, E-ISSN 1878-4216, Vol. 26, no 2, 303-306 p.Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to study short- and long-term effects of repeated ethanol administration on nociceptin/orphanin FQ (N/OFQ) tissue concentrations in rat brain with radioimmunoassay. Animals were given either ethanol (intraperitoneal) or saline for 13 consecutive days. N/OFQ levels were examined at 30 min, 5 days and 21 days after the last dose on day 13. Ethanol-treated rats had significantly decreased N/OFQ tissue concentration in the hippocampus at 30 min after the last dose. N/OFQ levels were decreased in the cingulate cortex at 5 days after cessation of ethanol administration whereas no significant changes were found at 21 days. There were no significant changes in N/OFQ tissue concentrations at any time point studied in the mesolimbic dopamine (DA) system, a brain area associated with ethanol-induced activation. However, the results indicate that repeated ethanol administration may induce short- and long-term changes in N/OFQ tissue concentrations in other brain regions innervated with dopaminergic neurons.

Place, publisher, year, edition, pages
2002. Vol. 26, no 2, 303-306 p.
Keyword [en]
ethanol, nociceptin, orphanin FQ, radioimmunoassay
National Category
Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-62593DOI: 10.1016/S0741-8329(00)00118-XISI: 000173005700013PubMedID: 11817508OAI: oai:DiVA.org:uu-62593DiVA: diva2:90504
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2017-11-30Bibliographically approved

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Nylander, Ingrid

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