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Correlates of pregnancy oestrogen, progesterone and sex hormone-binding globulin in the USA and China
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Clinical Chemistry)
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2002 (English)In: European Journal of Cancer Prevention, ISSN 0959-8278, Vol. 11, no 3, 283-293 p.Article in journal (Refereed) Published
Abstract [en]

The objective of this study is to examine perinatal correlates of oestradiol (E2), oestriol (E3), progesterone and sex hormone-binding globulin (SHBG) among pregnant women in the USA and China. Three hundred and four Caucasian women in Boston and 335 Chinese women in Shanghai were studied. Levels of E2, E3, progesterone and SHBG were measured in maternal blood at weeks 16 and 27 of gestation, and correlated with maternal, gestational and perinatal characteristics. Height, weight and body mass index (BMI) before pregnancy is inversely associated with E2 and SHBG, whereas E3 is inversely associated with height and progesterone is inversely associated with weight and BMI. A previous live birth is associated with lower E2 and SHBG in the index pregnancy. Total gestation duration is inversely associated with E2, E3 and progesterone, whereas weight gain during pregnancy is inversely associated with progesterone and SHBG. In the US, pregnancies with female fetuses are characterized by significantly reduced progesterone. Pregnancy hormones are associated with several maternal, gestational and neonatal characteristics.

Place, publisher, year, edition, pages
2002. Vol. 11, no 3, 283-293 p.
Keyword [en]
Maternal characteristics, oestradiol, oestriol, oestrogen, perinatal characteristics, pregnancy, progesterone, SHBG
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-62598PubMedID: 12131662OAI: oai:DiVA.org:uu-62598DiVA: diva2:90509
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2009-11-09Bibliographically approved

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