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Establishment and Dysfunction of the Blood-Brain Barrier
Univ So Calif, Keck Sch Med, Dept Physiol & Biophys, Los Angeles, CA 90089 USA.;Univ So Calif, Keck Sch Med, Zilkha Neurogenet Inst, Los Angeles, CA 90089 USA..
Univ So Calif, Keck Sch Med, Dept Physiol & Biophys, Los Angeles, CA 90089 USA.;Univ So Calif, Keck Sch Med, Zilkha Neurogenet Inst, Los Angeles, CA 90089 USA..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology.
Univ So Calif, Keck Sch Med, Dept Physiol & Biophys, Los Angeles, CA 90089 USA.;Univ So Calif, Keck Sch Med, Zilkha Neurogenet Inst, Los Angeles, CA 90089 USA..
2015 (English)In: Cell, ISSN 0092-8674, E-ISSN 1097-4172, Vol. 163, no 5, 1064-1078 p.Article in journal, Editorial material (Other academic) Published
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Abstract [en]

Structural and functional brain connectivity, synaptic activity, and information processing require highly coordinated signal transduction between different cell types within the neurovascular unit and intact blood-brain barrier (BBB) functions. Here, we examine the mechanisms regulating the formation and maintenance of the BBB and functions of BBB-associated cell types. Furthermore, we discuss the growing evidence associating BBB breakdown with the pathogenesis of inherited monogenic neurological disorders and complex multifactorial diseases, including Alzheimer's disease.

Place, publisher, year, edition, pages
2015. Vol. 163, no 5, 1064-1078 p.
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Cell and Molecular Biology
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URN: urn:nbn:se:uu:diva-276935DOI: 10.1016/j.cell.2015.10.067ISI: 000366044700008PubMedID: 26590417OAI: oai:DiVA.org:uu-276935DiVA: diva2:905678
Available from: 2016-02-23 Created: 2016-02-16 Last updated: 2017-11-30Bibliographically approved

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Betsholtz, Christer

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